婴儿胆汁淤积性肝病的诊断及鉴别诊断

Diagnosis and differential diagnosis of infantile cholestasis disease

婴儿胆汁淤积性肝病是婴儿期（包括新生儿期）常见的肝脏疾病，涉及肝内和肝外多种病因，首先应鉴别胆道闭锁和非胆道闭锁，依据临床、实验室、影像学和肝脏病理进行综合评估诊断。肝内胆汁淤积性肝病病因甚多，遗传因素已成为研究热点，病因及适当治疗可显著改善预后。

Infantile cholestasis disease is a common liver disease in infancy （including neonatal period）. It is caused by intra - or extrahepatic factors. First of all, a differential diagnosis of biliary atresia and non - biliary atresia intrahepatic cholestasis needs to be made. The diagnosis should be made according to clinical manifestation, laboratory test results,imaging results and liver pathology. Numerous etiologies can cause intrahepatic cholestasis. Genetic factors are research focus now. Therapy on the etiologies is an effective therapeutic measure.