摘要
牙源性干细胞对口腔领域的新型细胞疗法的发展具有重要意义,引起广泛的关注。在牙体组织发育或再生过程中,牙源性干细胞也非常适合研究细胞过程。牙囊中的多能未分化细胞是牙源性干细胞的一种,这些细胞已被用于分化为成牙骨质细胞和成骨细胞的细胞过程的研究,对于牙周组织具有重要意义。该文关于信号通路、转录因子、细胞外基质蛋白对牙囊细胞成骨分化的研究作一综述。
The discovery of dental stem cells has received extensive attention because of its significance for the development of novel cellular therapies in dentistry. Dental stem cells are also excellent for studies on cellular processes during dental tissue development or regeneration. Multipotent undifferentiated cells in the dental follicle are one example of dental stem cells,having been used in studies on cellular processes during the differentiation into alveolar osteoblasts and cementoblasts,which are important for periodontal tissue.This review summarizes current knowledge about the influence of signaling pathways,transcription factors and extracellular matrix proteins on the osteogenic differentiation of dental follicle cells.
作者
杨爽
胡伟平
YANG Shuang; HU Weiping(Department of Prosthodontics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China)
出处
《口腔医学》
CAS
2018年第10期930-933,946,共5页
Stomatology
基金
黑龙江省自然科学基金(H2013101)
关键词
牙囊细胞
成骨分化
转录因子
信号转导
牙周组织
dental follicle cells
osteogenic differentiation
transcription factors
signaling pathways
periodontium
