反流性食管炎危险因素分析

Analysis of risk factors of reflux esophagitis

目的探讨反流性食管炎(reflux esophagitis, RE)发病的危险因素方法对2016年9月至2017年8月于首都医科大学宣武医院就诊的患者进行问卷调查,实验组为胃镜证实为反流性食管炎的患者,共361例;对照组为无烧心、反流等典型症状的健康体检者,共328例,包括一般人口信息、生活方式、饮食习惯、PHQ-9抑郁量表及GAD-7焦虑量表。结果 RE组男女比例为1∶1.20,对照组男女比例为1∶1.33,2组性别比较差异无统计学意义(P>0.05)。2组年龄比较差异亦无统计学意义。多因素logistic回归分析显示,低教育水平、饮茶、喜甜食、进食过饱、睡前进食、喜过酸食物、焦虑、抑郁、低枕入睡及便秘与RE发病密切相关(P <0.05)。Ordinal Logistic回归分析,显示低枕入睡和RE的严重程度呈正相关(P <0.05)。结论反流性食管炎的发生与某些生活习惯、饮食习惯及精神因素密切相关。有低枕入睡习惯者,反流性食管炎病情更为严重。

Objective To investigate the risk factors of reflux esophagitis（RE）. Methods From September 2016 toAugust 2017, a total of 689 patients at Xuanwu Hoipital Capital Medical University participated in the survey. They were de-vided into RE group（patients diagnosed as reflux esophagitis by gastroscopy, a total of 361 cases） and control group（healthypeople without heartburn, reflux and other typical symptoms, a total of 328 cases）. Both groups were all surveyed, includinggeneral demographic data, habits, diet, PHQ-9 depression scale and GAD-7 anxiety scale. Results The ratio of male to fe-male in RE group was 1∶1.20, the ratio of male to female in control group was 1∶1.33, there was no significant differencebetween two groups（P〉0.05）. The age of the two groups was also not statistically significant. Multivariate logistic regressionanalysis showed that low education level, drinking tea, sweet sweets, eating too much, eating before going to bed, eating toomuch sour food, anxiety, depression, low occipital position and constipation were closely related to the pathogenesis of RE（P〈0.05）. There was a positive correlation between low occipital position and the severity of RE（P〈0.05）. Conclusion The occurrence of RE is closely related to some lifestyles. The patients with eating habits and mental factors, including loweducation level,drinking tea, sweet sweets, eating too much, eating before going to bed, eating too much sour food, low occipi-tal position, constipation, anxiety and depression may be more likely to develop RE. Patients with RE who have low occipitalposition are more serious.