摘要
以往,氢气(H_2)被认为是生理上的惰性气体。但是,近年来的研究表明,H_2具有抗氧化、抗炎、抗凋亡等作用,在多种疾病模型中有显著的治疗效果,且在多项临床试验中也得到了较好的验证。心脑血管疾病是全世界致死率最高的疾病,严重威胁人类生命健康。本文就H_2在心脑血管疾病中的生物医学效应及其可能的分子机制进行综述,以期全面介绍H_2在该类疾病中的生物医学效应的最新研究进展,并为某些心脑血管疾病的临床治疗提供新思路。
For a long time, hydrogen (H2) has been considered as a physiological inert gas. However, recent studies have demonstrated that molecular H2 exerts significant therapeutic effects on various disease models due to its antioxidative, anti-inflammatory and anti-apoptotic capabilities, which have also been well confirmed in many clinical trials. Cardiovascular and cerebrovascular diseases (CCVDs) are the leading cause of death in the world, constituting a serious threat to human life and public health. In this paper, we reviewed the latest research progress of the biomedical effects of H2 in CCVDs and its possible molecular mechanisms, in the hope of providing new clues for the treatment of some CCVDs.
作者
薛俊莉
宋国华
秦树存
XUE Jun-Li;SONG Guo-Hua;QIN Shu-Cun(Key Laboratory of Atherosclerosis in Colleges and Universities of Shandong Province,Institute of Atherosclerosis of Taishan Medical University,Taishan Institute for Hydrogen Biomedical Research,Taian 271000,China)
出处
《生理学报》
CAS
CSCD
北大核心
2018年第5期557-564,共8页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No81770855
81670422)
the Taishan Scholars Foundation of Shandong Province
China(No.ts201511057
tsqn20161045)
关键词
氢气
心脑血管疾病
生物医学效应
分子机制
hydrogen
cardiovascular and cerebrovascular diseases
biomedical effects
molecular mechanism