叶酸受体介导的宫颈特殊染色在宫颈异常病变中的临床筛查意义

Clinical Screening Significance of Folate Receptor-Mediated Tumor Diagnosis for Cervical Lesions

目的探讨叶酸受体介导的宫颈特殊染色与细胞学检查两种方法对宫颈异常病变的临床筛查意义。方法对1 968例患者进行叶酸受体介导的宫颈特殊染色检查与细胞学检查,以病理检查所得结果为标准,比较两种检查方法的诊断效能,判断二者对宫颈癌的临床诊断价值。结果叶酸受体介导的宫颈特殊染色与细胞学检查的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值比较,差异均无统计学意义(P>0.05)。结论叶酸受体介导的宫颈特殊染色法与液基细胞学检查法在宫颈癌筛查中的效果相当,但叶酸受体介导的宫颈特殊染色法的优势更明显。

Objective To explore the clinical screening significance of folate receptor-mediated tumor diagnosis for cervical lesions. Methods 1 968 cases of patients received folate receptor-mediated tumor diagnosis and cytological examination. Based on the results obtained by pathological examination, the diagnostic efficacy was compared to determine the clinical diagnostic value of the two methods for cervical cancer. Results No significant difference was found in the positive detection rate, sensitivity, specificity, positive predictive value and negative predictive value between folate receptor-mediated tumor diagnosis and cytological examination （P 〉0.05）. Conclusions The folate receptor-mediated tumor diagnosis and liquid-based cytological examination are comparable in the screening of cervical cancer, but the former has more obvious advantages.