两项尿液新检测指标在糖尿病肾病诊断中的作用

The role of two new urine test indicators in the diagnosis of diabetic nephropathy

目的探讨尿胱抑素C(Cys-C)、尿纤维结合蛋白(UFn)对诊断糖尿病肾病(DN)患者的临床价值。方法选取DN患者180例、临床诊断为糖尿病但无肾损害的高血糖患者90例和体检健康者50例进行检测,并比较DN患者血清HbA1c和尿中mAlb、Cys-C、Fn水平,计算各项指标均值、阳性率,分析其对DN患者的诊断价值。结果 DN患者尿mAlb、Cys-C、Fn均值、阳性率,均高于同期高血糖组和对照组(P<0.05),提示尿mAlb与空腹血糖的控制水平呈正相关,且Cys-C与尿mAlb呈正相关性。结论尿Cys-C与UFn两项检测指标在DN的早期诊断中有重要临床价值,值得推广。

Objective Email： zhenzhuyang@ 163. com To investigate the clinical value of urinary cystatin C（ Cys-C） and urinary fibronectin（ UFn） in the diagnosis of diabetic nephropathy（ DN）. Methods The patients with diabetic nephropathy（ 180 cases）and diabetes mellitus without kidney damage（ 90 cases） were selected and compared with the healthy controls（ 50 cases）. The levels of m Alb,Cys-C and UFn proteins were calculated,and the mean values and positive rates of each index were calculated and analyzed for the diagnostic value of patients with DN. Results The mean and positive rates of m Alb,Cys-C and UFn in patients with DN were higher than those in healthy controls at the same time（ P〈0. 05）. The level of urine microalbumin was positively correlated with the control level of fasting blood glucose,while Cys-C,UFn were positively correlated with urinary microalbumin. Conclusion The combined detection of Cys-C and UFn can be used as a diagnostic indicator of DN.