乙肝孕妇25羟基维生素D与HBV-DNA相关性研究

The association between serum 25-hydroxyvitamin D and HBV-DNA in pregnant women with chronic hepatitis B

目的探讨乙肝孕妇血清25羟基维生素D与乙肝病毒复制水平之间的相关性。方法收集79例慢性乙型肝炎孕妇、74例正常孕妇的空腹血清标本,定量检测血清25羟基维生素D及乙肝孕妇的乙型肝炎病毒脱氧核糖核酸(HBV-DNA)。结果乙肝孕妇血清25羟基维生素D为(8.33±3.74)ng/m L,明显低于正常孕妇的(14.42±7.04)ng/m L(P<0.05)。维生素D水平受到季节影响,乙肝孕妇在夏季和冬季25羟基维生素D均明显低于正常孕妇(P<0.05),但未发现乙肝孕妇及正常孕妇在夏季与冬季变化时25羟基维生素D的明显差异(P>0.05)。34例HBV-DNA阳性乙肝孕妇的25羟基维生素D浓度与45例HBV-DNA阴性乙肝孕妇相比较差异无统计学意义(P>0.05)。在HBV-DNA阳性的乙肝孕妇中未发现25羟基维生素D与HBV-DNA之间存在显著的相关性(P>0.05)。结论乙肝孕妇存在普遍且严重的维生素D缺乏,建议该类人群进行维生素D的补充。未发现乙肝孕妇HBV-DNA与血清25羟基维生素D之间的相关性。

Objective To investigate the correlation between serum 25-hydroxyvitamin D and hepatitis B virus DNA in pregnant women with chronic hepatitis B. Methods Serum 25-hydroxyvitamin D level among 79 pregnant women with chronic hepatitis B virus infection and 74 healthy pregnant women were measured. Meanwhile we tested HBV-DNA quantification for the pregnant women with chronic hepatitis B. Results The mean 25-hydroxyvitamin D concentration in pregnant women with chronic hepatitis B was（ 8. 33 ± 3. 74） ng/mL,which was lower than that in healthy pregnant women significantly（ P〈0. 05）. Vitamin D status was assessed in relation to seasonal variation,in both summer and winter,its level in pregnant women with chronic hepatitis B was obviously lower than that in healthy pregnant women（ P〈0. 05）. There was no significant difference for serum vitamin D concentration of both pregnant women with chronic hepatitis B and healthy pregnant women between summer and winter（ P〉0. 05）. Among pregnant women with chronic hepatitis B,25-hydroxyvitamin D concentration between 34 HBV-DNA positive cases and 45 HBV-DNA negative cases showed no significant changes（ P〉0. 05）. Furthermore,the significantly statistical correlation between 25-hydroxyvitamin D concentration and HBV-DNA level in HBV-DNA positive pregnant women was not observed（ P〈0. 05）. Conclusion Pregnant women with chronic hepatitis B are prone to encounter severe 25-hydroxyvitamin D deficiency,which implies these patients are suggested to uptake vitamin D supply. And the correlation between 25-hydroxyvitamin D concentration and HBV-DNA was not observed in pregnant women with chronic hepatitis B.