更年期女性代谢性疾病发病及干预进展

Progress in the onset and intervention of metabolic diseases in menopausal women

更年期是指卵巢功能逐渐衰退的过程。这一过程主要因雌激素水平的波动和下降而导致内分泌和各种代谢紊乱。代谢综合征(MS)是指人体蛋白质、脂肪、碳水化合物等物质发生代谢紊乱而导致高血压、高血脂或高血糖的一组症候群。经历激素变化的更年期女性易发生或加重代谢紊乱,如不及时干预,会导致不可逆的2型糖尿病、高血压、心血管疾病等代谢性疾病,甚至老年痴呆,给更年期女性近期和远期的健康和生活质量造成影响。该文针对更年期相关的代谢性疾病的发病情况、可能的机制与特征,以及干预进展进行综述,为进一步做好更年期保健,改善更年期代谢性问题,预防更年期代谢性疾病,提高更年期女性的生活质量提供参考。

Menopause refers to the gradual decline of ovarian function.This process is prone to endocrine and metabolic disorders due to fluctuations and decreases in estrogen levels.Metabolic syndrome（MS）is a group of syndromes that lead to hypertension,hyperlipidemia or hyperglycemia due to metabolic disorders of proteins,fats,carbohydrates and other substances.Menopausal women who experience hormonal changes are prone to developing or exacerbating metabolic disorders.If they are not intervened in time,they can lead to irreversible metabolic diseases such as type 2 diabetes,hypertension,cardiovascular disease,and even Alzheimer＇s disease,which has an impact on the health and quality of life of menopausal women in the near and long term.This article reviewed the incidence,possible mechanism and characteristics of metabolic diseases related to menopause,as well as the progress of intervention,aiming to further improve menopausal health care,improve menopausal metabolic problems,prevent menopausal metabolic diseases,and improve the quality of life of menopausal women.