舒肝解郁胶囊对老年阿尔茨海默病伴抑郁病人5-羟色胺和多巴胺水平的影响

Effect of Shugan Jieyu capsule on 5-hydroxytryptamine and dopamine levels in elderly patients with Alzheimer's disease complicated with depression

目的观察舒肝解郁胶囊对老年阿尔茨海默病(AD)伴抑郁病人血清5-羟色胺(5-HT)、多巴胺(DA)水平的影响。方法 90例老年AD伴抑郁病人随机分为对照组与观察组,每组45例。2组病人均给予临床常规口服多奈哌齐和康复治疗,观察组在此基础上加用舒肝解郁胶囊。比较2组治疗前及治疗后第8周和第12周汉密尔顿抑郁量表(HAMD)评分、蒙特利尔认知评估量表(MoCA)评分及血清5-HT和DA水平。结果观察组治疗后第8周和第12周HAMD评分较治疗前显著降低,MoCA评分显著提高,5-HT、DA水平较治疗前显著升高,且与对照组比较差异有统计学意义(P<0. 05)。结论舒肝解郁胶囊治疗老年AD伴抑郁病人疗效确切,其机制可能与其提高老年AD伴抑郁病人血清5-HT和DA水平有关。

Objective To observe the effect of Shugan Jieyu capsule on 5-hydroxytryptamine（ 5-HT） and dopamine（ DA） levels in elderly patients with Alzheimer＇s disease（ AD） complicated with depression. Methods Ninety elderly patients with AD complicated with depression were randomly divided into control group and observation group,with 45 cases in each group. Routine clinical treatment and rehabilitation treatment were given in two groups. On the basis of routine treatment,the observation group received Shugan Jieyu capsule for 12 weeks. The scores of Hamilton Depression Scale（ HAMD） and Montreal Cognitive Assessment（ Mo CA） were evaluated,and the levels of 5-HT and DA were detected before treatment and 8,12 weeks after treatment in two groups. Results After 8 and 12 weeks of treatment,the HAMD score was decreased and the Mo CA score and the levels of 5-HT and DA were increased in observation group,which showed significant difference compared with the control group（ P〈0. 05）. Conclusions Shugan-jieyu capsule in the treatment of elderly AD patients complicated with depression is effective,and the mechanism may be related to the increase of serum levels of 5-HT and DA.