创新抗肿瘤药物A111P小鼠急性毒性研究

Acute toxicology research of anti-tumor drugs A111P on mice

目的研究创新抗肿瘤药物A111P小鼠急性毒性情况,为新药研发提供依据。方法选用昆明小鼠为研究对象,采用上下法和半数致死量法考察创新抗肿瘤药物A111P的急性毒性情况。结果 A111P小鼠腹腔注射给药,上下法估算半数致死量(median lethal dose,LD_(50))为327.3 mg/kg,95%CI为175~550 mg/kg;半数致死量法表明LD_(50)为245.875 mg/kg,95%CI为201.854～308.474 mg/kg。结论创新抗肿瘤药物A111P安全性较好,安全范围较大,具有较好的应用前景。

Objective To study the acute toxicology of anti-tumor drug A111 P on mice,and provide foundation for clinical research. Methods KM mice were selected in this study. High and low and median lethal dose were used to study the acute toxicity of anti-tumor drugs A111 P. Results The estimated LD50 of A111 P was 327.3 mg/kg,and the 95%CI was 17-550 mg/kg in high and low doasge. The LD50 of A111 P was 245.875 mg/kg,and the 95%CI was 201.854～308.474 mg/kg in classical median lethal dose. Conclusion Anti-tumor drugs A111 P had low actue toxicity and could be developmented as new drug.