摘要
登革热是由Ⅰ、Ⅱ、Ⅲ和Ⅳ型登革病毒引起的急性传染病,主要通过埃及伊蚊和白纹伊蚊传播,引起广泛流行。登革病毒是一种单股正链的RNA黄病毒,依次编码3种结构蛋白,即包膜蛋白(E)、膜蛋白(M)和衣壳蛋白(C),和7个非结构蛋白(NS1、NS2A、NS2B、NS3、NS4A、NS4B和NS5),NS1蛋白在病毒感染、复制及病理过程中起着重要作用。本文就NS1蛋白在登革病毒检测及免疫预防方面的研究进展作一综述。
Dengue is an acute infectious disease caused by dengue viruses of type Ⅰ,Ⅱ,Ⅲ and Ⅳ,which is transmittedmainly through Aedes aegypti and Aedes albopictus and causes widespread epidemic. Dengue virus（DENV）is a single-stranded,positive-sense RNA flavivirus that has three structural proteins,envelope（E）,matrix（M）and capsid（C）proteins,as well as seven nonstructural proteins（NS1,NS2 A,NS2 B,NS3,NS4 A,NS4 B and NS5）. NS1 protein plays animportant role in virus infection,replication and pathological process. This article mainly discusses the research progress inthe application of NS1 protein in dengue virus detection and immune prevention.
作者
牛丛
王淼
万成松
张仁利
NIU Cong;WANG Miao;WAN Cheng-song;ZHANG Ren-li(School of Public Health, Southern Medical University, Guangzhou, Guangdong 510515;Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518055, China)
出处
《热带医学杂志》
CAS
2018年第10期1394-1397,共4页
Journal of Tropical Medicine
基金
国家自然科学基金(81273075)
关键词
NS1蛋白
登革热
病毒检测
疫苗
NS1 protein
Dengue fever
Virus detection
Vaccine
