调强放疗与常规放疗对早期乳腺癌患者保乳术后辅助治疗效果的影响

Effect of Intensity-modulated Radiotherapy and Conventional Radiotherapy on Adjuvant Therapy after Breast-conserving Surgery in Patients with Early Breast Cancer

目的通过对早期乳腺癌患者保乳术后采用调强放疗与常规放疗的应用效果进行分析,进而为找出更好的辅助治疗方式提供依据。方法选取2014年5月—2016年5月该院来进行早期乳腺癌保乳术治疗的102例患者,按照随机原则将其平均分为观察组与对照组,每组51例;对观察组患者实施调强放疗,对对照组患者实施常规放疗,对比二者疗效。结果治疗结束后,术后对患者进行随访发现,观察组患者的局部控制率为96.08%、无瘤生存率为96.08%、远处转移率为0.00%,根据数据分析观察组要好于对照组患者,但比较差异无统计学意义(χ~2=0.020、0.020、0.821,P>0.05);在急性放射性皮肤反应发生率方面,观察组中共有46例患者出现1级急性放射性皮肤反应、5例2级急性放射性皮肤反应;而在对照组中共有37例患者出现1级急性放射性皮肤反应、14例2级急性放射性皮肤反应(P<0.05)。结论在对早期乳腺癌患者实施保乳术后实时调强放疗的辅助治疗方式在急性放射性皮肤反应发生概率方面要好于常规放疗方式,值得在临床中加以推广和应用。

Objective To analyze the application effect of intensity-modulated radiotherapy and conventional radiotherapy for breast-conserving patients with early breast cancer, and to provide a basis for finding better adjuvant treatment. Methods A total of 102 patients who underwent breast-conserving breast-conserving surgery from May 2014 to May 2016 were randomly divided into observation group and control group, with 51 case in each group. The patients in the observation group were treated with intensity-modulated radiotherapy, and the patients in the control group were treated with conventional radiotherapy to compare the curative effects. Results After the treatment, the patients were followed up. The local control rate of the observation group was 96.08%, the tumor-free survival rate was 96.08%, and the distant metastasis rate was 0.00%, according to the data analysis, the observation group was better than the control group, the difference was not statistically significant （χ2=0.020,0.020,0.821,P〉0.05）. In the incidence of acute radiation skin reaction, 46 patients in the observation group developed grade 1 acute radioactive skin reaction, 5 cases of grade 2 acute radiation skin reaction; in the control group, 37 patients had grade 1 acute radiation skin reaction and 14 grade 2 acute radiation skin reactions （P〈0.05）. Conclusion The adjuvant treatment of real-time intensity-modulated radiotherapy after breast-conserving surgery for patients with early breast cancer is better than conventional radiotherapy in the incidence of acute radiation-induced skin reactions. It is worthy of promotion and application in clinical practice.