长链非编码RNA影响胶质瘤发病机制的研究进展

Advances in the pathogenesis of long non-coding RNA in glioma

胶质瘤是颅内最常见的恶性肿瘤,长链非编码RNA(lncRNA)是一类不能翻译成为蛋白质的RNA,lncRNA对人体生物学功能及疾病的发生发展有重要作用。lncRNA的作用包括表观遗传学调节、控制基因转录、与miRNA相互作用、miRNA的前体等,这些作用广泛存在且影响胶质瘤发病机制。lncRNA对于胶质瘤细胞的增殖、侵袭、转移有很多调节作用,对于胶质瘤的诊断及治疗有很多指导作用。

Glioma is one of the most common intracranial tumors. Long non-coding RNA（lncRNA） cannot be translated into proteins but has many important effects on bio-functions and diseases of human beings. The functions of lncRNA includes epigenetic regulation, transcription regulation, lncRNA-miRNA interation, being precursor of miRNA and these functions play important role in pathogenesis of glioma, ln- cRNA has many regulatory effects on the proliferation, invasion and metastasis of glioma cells, and plays a guiding role in the diagnosis and treatment of glioma, lncRNA influence the proliferation, migration and invasion of glioma and the study of lrlcRNA mean a lot in the treatment of patients with glioma.