干细胞及基因治疗勃起功能障碍的研究进展

Research progress of stem cells and gene therapy for erectile dysfunction

勃起功能障碍(ED)作为一种普遍的健康问题影响了众多男性及其伴侣的生活质量。现有的ED治疗手段存在着诸多弊端。干细胞由于其具有自我更新和分化成各种细胞类型的功能,基因治疗方法主要集中于一氧化氮合酶/环磷酸鸟苷(NOS/cGMP)通路各种递质和酶的调节、生长因子、多肽及通道蛋白方面的研究,使其两者在ED治疗领域具有广阔的应用前景。近年来ED的干细胞及基因治疗研究已初显成效,本文旨在对该领域的最新研究进展作一综述。

Erectile dysfunction （ED） is a highly prevalent health problem with considerable impact on the quality of men and their partners. There are many drawbacks in the existing ED treatment. Stem cells have the function of self-renewal and differentiation into various cell types. L-ene therapy mainly tocuses on the regulation of various transmitters and enzymes in nitricoxide synthase/cyclic guanosine monophosphate （NOS/c GMP） pathway, growth factors, peptides and channel proteins, which make them have broad application prospects in the field of ED treatment. In recent years, stem cell and gene therapy of ED have achieved initial results. This article aims to review the latest research progress in this field.