康复新液联合益生菌治疗活动期轻中度溃疡性结肠炎的疗效

Curative Effect of Kangfuxin Liquid Combined with Probiotics on Active Mild-to-Moderate Ulcerative Colitis

目的探讨康复新液联合益生菌治疗活动期轻中度溃疡性结肠炎(UC)的临床疗效。方法将104例活动期轻中度UC患者分为按治疗方法的不同分为对照组和观察组,每组52例。2组均采用常规治疗,同时采用双歧杆菌乳杆菌三联活菌片治疗。在此基础上,观察组采用康复新液行保留灌肠治疗。比较2组治疗8周后中医症候(腹痛、腹泻、黏液脓血便、里急后重)评分和治疗前、治疗8周后血清丙二醛(MDA)、白细胞介素-7(IL-7)、白细胞介素-23(IL-23)水平,血清谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性及不良反应情况。结果与对照组比较,观察组治疗8周后腹痛、腹泻、黏液脓血便、里急后重评分及血清MDA、IL-7、IL-23水平均降低,血清GSH-Px、SOD活性均升高(均P<0.05)。2组在治疗过程中均未见明显的不良反应。结论康复新液联合益生菌治疗活动期轻中度UC疗效显著,且具有较高的安全性。

Objective To explore the clinical curative effect of Kangfuxin liquid combined with probiotics on active mild-to-moderate ulcerative colitis（UC）. Methods A total of 104 patients with active mild-to-moderate UC were divided into control group and observation group,with 52 patients in each group.Both groups were given conventional treatment and triple viable bacteria tablets containing Bifidobacterium and Lactobacillus.On this basis,the observation group was additionally treated with Kangfuxin liquid via retention enema.After treatment for 8 weeks,the traditional Chinese medicine symptoms（abdominal pain,diarrhea,tenesmus,mucopurulent stool,tenesmus） were compared between the two groups.Serum levels of malondialdehyde（MDA）,interleukin-7（IL-7） and interleukin-23（IL-23） and activities of glutathione peroxidase（GSH-Px） and superoxide dismutase（SOD） were measured before and after treatment for 8 weeks. Results Compared with control group,Kangfuxin liquid increased the scores of abdominal pain,diarrhea,mucopurulent stool and tenesmus and serum levels of MDA,IL-7 and IL-23,and increased the activities GSH-Px and SOD after 8 weeks of treatment（ P 〈0.05）.No obvious adverse reactions were found during the treatment in both groups. Conclusion Kangfuxin liquid combined with probiotics is effective and safe for treating active mild-to-moderate UC.