急性前循环脑梗死患者MCP-1、VE-cadherin水平对疾病严重程度预测的价值

Predict the severity of the disease by detecting the levels of MCP-1 and VE-cadherin in patients with acute anterior circulation cerebral infarction

目的:探讨急性前循环脑梗死患者中检测MCP-1、VE-cadherin水平对疾病严重程判定价值。方法:选取急性前循环脑梗死患者60例的临床资料行回顾性分析,根据患者脑梗死后临床表现分为进展性脑梗死组、非进展性脑梗死组,根据梗死部位分为完全脑梗死组、部分脑梗死组,根据病情严重程度、神经功能缺损程度分为轻度组、中度组、重度组,分别比较各组间MCP-1、VE-cadherin水平。结果:进展性脑梗死组患者MCP-1、VE-cadherin水平均高于非进展性脑梗死组患者,差异有统计学意义(P <0. 05);完全脑梗死组患者MCP-1、VE-cadherin水平均高于部分脑梗死组患者,差异有统计学意义(P <0. 05);轻度组、中度组、重度组患者MCP-1、VE-cadherin水平依次升高,差异有统计学意义(P <0. 05)。结论:急性前循环脑梗死患者中检测MCP-1、VE-cadherin水平可反映患者疾病严重程度。

Objective To investigate the detection of MCP - 1 and VE - cadherin levels in patients with acute anterior circulation cerebral infarction to determine the value of disease severity. Method The clinical data of 60 case of acute anterior circulation cerebral infarction patients, they were divided into progressive cerebral infarction group, non -progressive cerebral ilffarction group;complete cerebral ilffarction group, partial cerebral infarction group;mild group, moderate group and severe group. The lev- els of MCP - 1 and VE - cadherin were compared. Results The levels of MCP - 1 and VE - cadherin in patients with progressive cerebral infarction were significantly higher than those in non - progressing cerebral infarction patients （ P 〈 0. 05 ）. The levels of MCP - 1 and VE - cadherin in patients with complete cerebral infarction were significantly higher than those in patients with partial cerebral infarction （ P 〈 0. 05 ）. The levels of MCP - 1 and VE - cadherin in mild, moderate and severe groups increased in turn, with statistical significance （ P 〈 0. 05 ）. Conclusion The levels of MCP - 1 and VE - cadherin in patients with acute anterior circulation cerebral infarction may reflect the severity of the disease.