某院丁丙诺啡透皮贴不良反应原因分析及干预效果评价

Causes Analysis of Adverse Drug Reactions Induced by Buprenorphine Transdermal System and Evaluation of Intervention Effect in a Hospital

目的促进丁丙诺啡透皮贴的临床安全用药。方法药师统计医院2017年3月至5月丁丙诺啡透皮贴的临床用药情况,剖析发生不良反应的原因并实施针对性干预。干预后,采用相同方法统计2017年9月至11月该贴剂的临床用药情况,并与干预前进行对比分析。结果药师干预后,丁丙诺啡透皮贴不良反应减少23例,不良反应发生率下降5. 68%,且用药目的、联合用药、用药温度、使用贴数、用药对象更趋合理。结论通过药师干预,该院丁丙诺啡透皮贴不良反应发生率有所降低,但仍存在一些不合理用药,需进一步改善。

Objective To promote clinical safe medication of Buprenorphine Transdermal System. Methods From March to May in 2017,the clinical use of Buprenorphine Transdermal System in our hospital was statistically analyzed,the causes of adverse drug reac- tions（ADRs） were analyzed and targeted intervention was carried out. After intervention,the clinical use of Buprenorphine Transdermal System from September to November in 2017 was analyzed in the same method, and that was compared with before intervention. Results After intervention by pharmacists, the incidence of ADR induced by Buprenorphine Transdermal System was decreased by 23 cases, and the incidence rate of ADR was decreased by 5.68%.The purpose of drug use, the drug combination, the number of Buprenorphine Transdermal System, and the drug user were more reasonable. Conclusion Through the intervention of pharmacists,the incidence rate of ADR induced by Buprenorphine Transdermal System in our hospital has been decreased,but there are still some irrational use of drugs ,which need to be further improved.