酒精性脂肪肝代谢因子研究进展

Research progress of alcoholic fatty liver disease metabolic factors

乙醇对酒精性脂肪肝作用的分子机制已被广泛研究,但尚未完全了解。CYP2E1对乙醇诱发的脂质氧化应激具有重要作用;SREBPs和PPARs可以调控脂肪代谢,控制乙醇诱发的脂质过氧化作用;MAPK和HIF作为SREBPs和PPARs的上游调控元件,在酒精性脂肪肝致病机制中发挥着重要作用;脂联素1(Lipin-1)作为肝脏脂质代谢的关键调节剂,在酒精性脂肪肝形成中起着重要作用。鉴于这些分子在脂肪肝疾病生理过程中的关键作用,可以用于治疗和预防许多代谢和脂质相关的疾病。文章总结了SREBPs和PPARs与酒精性脂肪肝的关系,并且着重介绍了MAPK,HIF和Lipin-1及其上下游分子在酒精性脂肪肝发病机制中的作用。

The molecular mechanism of ethanol on alcoholic fatty liver disease has been extensively studied but not fully clearly. CYP2E1 plays an important role in the ethanol-induced lipid oxidative stress. SREBPs and PPARs can regulate the fat metabolism and control ethanol-induced lipid peroxidation. MAPK and HIF plays an important role in the pathogenesis mechanism which acts as upstream regulatory elements of SREBPs and PPARs in the alcoholic fatty liver. As a key regulator of the liver lipid metabolism, Lipin- 1 plays an important role in the development of alcoholic fatty liver. As the critical roles of the physiological processes of fatty liver disease research, it can be used to treat and prevent many metabolic and lipid-related diseases. This review summarizes the relationship between SREBPs, PPARs and alcoholic fatty liver disease, and introduces the role of MAPK, HIF, and Lipin- 1 and their upstream and downstream molecules in the pathogenesis of alcoholic fatty liver disease.