骨代谢标志物在多发性骨髓瘤中的临床应用

Clinical application of serum bone metabolic markers in multiple myeloma

目的:探讨多发性骨髓瘤(MM)病人血清中Ⅰ型前胶原氨基端延长肽(PINP)和Ⅰ型胶原蛋白羧基端β降解产物(β-CTX)水平及其临床意义。方法:利用电化学发光法来测定62例MM病人(MM组)和50名健康体检者(对照组)的血清PINP及β-CTX水平,比较不同临床分期的MM病人血清PINP和β-CTX水平的变化。结果:MM组病人血清PINP水平低于对照组(P <0. 01),β-CTX水平高于对照组(P <0. 01)。MM病人Ⅲ期β-CTX水平较Ⅰ期升高(P <0. 05),Ⅱ期与Ⅰ期、Ⅲ期差异均无统计学意义(P> 0. 05),PINP水平在三期之间差异均无统计学意义(P> 0. 05)。结论:血清PINP和β-CTX水平可用于评价MM病人的骨破坏程度,β-CTX水平较PINP对MM病人的预后评价更为敏感。

Objective： To investigate the levels of serum β-C-terminal telopeptide of typeⅠ collagen（β-CTX） and procollagenⅠN-terminal peptide（PINP） in patients with multiple myeloma（MM）,and its clinical significance.Methods： The serum levels of β-CTX and PINP in 62 MM patients（MM group） and 50 healthy people（control group） were detected using the electrochemiluminescence immunoassay.The serum levels of β-CTX and PINP in different clinical stages patients with MM were compared between two groups.Results： The serum levels of PINP and β-CTX in MM groups were lower and higher than those in control group,respectively（ P 〈 0.01 ）.The level of β-CTX in MM patients in stage Ⅲ was higher than that in stage Ⅰ （ P 〈0.05）,there was no statistical significance in the serum level of β-CTX between stage Ⅱ and stage Ⅰ or stage Ⅲ（ P 〉0.05）,and there was no statistical significance in the serum level of PINP among stage Ⅱ,stage Ⅰ and stage Ⅲ（ P 〉0.05）.Conclusions： The serum levels of PINP and β-CTX can be used to evaluate the degree of bone destruction in patients with MM.The level of β-CTX in evaluating the prognosis of patients with MM more sensitive than that of PINP.