高脂血症患者血管内皮微颗粒水平的表达及临床意义

Expression of Vascular Endothelial Microparticles in Patients with Hyperlipidemia and its Clinical Significance

目的:探讨高脂血症患者血管内皮微颗粒(EMPs)水平的表达及临床意义。方法:选取2016年5月到2017年8月期间我院收治的高脂血症患者64例,将其作为研究组。另选取同期在我院体检的健康志愿者50例作为对照组。检测两组研究对象的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、EMPs、压力-应变弹性系数(Ep)、顺应性(AC)、硬度指数(β)、脉搏波传导速度(PWV)水平,并采用Pearson相关性分析研究组患者EMPs水平与TC、TG、LDL-C、Ep、AC、β、PWV的相关性。结果:研究组血清中TC、TG、LDL-C、EMPs水平均显著高于对照组,差异有统计学意义(P<0.05);研究组的Ep、β、PWV均显著高于对照组,差异有统计学意义(P<0.05),但两组AC比较无统计学差异(P>0.05)。研究组患者的EMPs水平与TC、TG、LDL-C、Ep、β、PWV均呈正相关(r=0.567,0.645,0.763,0.426,0.398,0.364,P均<0.05)。结论:高脂血症患者的EMPs水平明显高于健康人群,且其水平与TC、TG、LDL-C、Ep、β、PWV均呈正相关。

Objective： To investigate the expression of vascular endothelial microparticles（EMPs） in patients with hyperlipidemia and its clinical significance. Methods： 64 patients with hyperlipidemia who were treated in our hospital from May 2016 to August 2017 were selected as the study group. In addition, 50 healthy volunteers who were examined in our hospital during the same period were selected as control group. The levels of triglycerides（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, EMPs, pressure strain（Ep） and compliance（AC）, hardness index（β） and pulse wave velocity（PWV） were detected. Pearson correlation analysis was used to study the correlation between EMPs level and TC, TG, LDL-C, Ep, AC, β and PWV in the patients of the study group. Results： The serum levels of TC, TG, LDL-C and EMPs in the study group were significantly higher than those in the control group, the differences were statistically significant（P〈0.05）. The levels of Ep, β and PWV in the study group were significantly higher than those in the control group, the differences were statistically significant（P〈0.05）, but there was no statistical difference in AC between the two groups（P〉0.05）. The EMPs levels of the patients in the study group were positively correlated with TC, TG, LDL-C, Ep, β and PWV（r=0.567, 0.645,0.763, 0.426, 0.398, 0.364, all P〈0.05）. Conclusion： The level of EMPs in patients with hyperlipidemia is higher than that in healthy people, and its level are positively correlate with TC, TG, LDL-C, Ep, βand PWV.