内镜揭盖术与唇齿沟径路切除术治疗鼻前庭囊肿患者的疗效及对炎性因子的影响

Nasal Vestibular Cyst: Curative Effects and Impact of Endoscopic Resection and Labiodental Sulcus Path Resection on Inflammatory Factors

目的:研究内镜揭盖术(ER)与唇齿沟径路切除术(LSPR)治疗鼻前庭囊肿(NVC)患者的临床疗效及对炎性因子的影响。方法:选择2015年7月至2017年6月来我院就诊的NVC患者106例,依据随机数字表法分别纳入ER组(53例)及LSPR组(53例)。ER组行ER治疗,LSPR组行唇齿沟径路切除术。观察两组术中出血量、手术时间、术后创口愈合时间、术后24 h疼痛评分及上皮化时间,两组术前、术后7 d白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平,两组术后并发症及复发情况。结果:ER组术中出血量、手术时间、术后创口愈合时间、术后24h疼痛评分及上皮化时间等手术指标均低于LSPR组,差异有统计学意义(P<0.05);术后7 d,两组IL-6、IL-8、TNF-α及CRP水平均低于治疗前,且ER组低于LSPR组,差异有统计学意义(P<0.05);ER组术后并发症发生率7.55%、术后复发率3.77%,均低于LSPR组的22.64%、20.75%,差异均有统计学意义(P<0.05)。结论:与LSPR相比较,ER治疗NVC创伤小,恢复快,可有效降低术后炎性因子水平,术后并发症及复发率低,值得临床应用。

Objective： To study the clinical efficacy of endoscopic resection（ER） and labiodental sulcus path resection（LSPR） in treatment of patients with nasal vestibular cyst（NVC） and influence on the Inflammatory factors of patients. Methods： A total of 106 NVC patients, who were admitted to Guangyuan Central Hospital of Sichuan Province from July 2015 to June 2017, were randomly divided into ER group（n=53） and LSPR group（n=53）. The ER group was treated by ER, and the LSPR group was treated by labiodental sulcus path resection. The intraoperative bleeding volume, the operation time, the time of wound healing, pain scores 24 h after operation,the epithelial time, the levels of IL-6, IL-8, TNF-α and CRP before operation and 7 days after operation, the postoperative complications andrecurrence were observed in the two groups. Results： The intraoperative bleeding volume, the operation time, the time of wound healing, the pain scores 24 h after operation and the epithelial time in ER group were lower than those in LSPR group（P〈0.05）. 7 days after operation, the levels of IL-6, IL-8, TNF-α, CRP in the two groups were lower than those before operation, and the ER group was lower than the LSPR group, the difference was statistically significant（P〈0.05）. The incidence of postoperative complications（5.55%）, and recurrence rate（3.77%） in ER group were lower than those（22.64%, 20.75%） in LSPR group, the difference was statistically significant（P〈0.05）. Conclusion： Compared with LSPR, in the treatment of NVC, ER can effectively reduce the levels of postoperative inflammatory factors, with less trauma, faster recovery, low incidence of postoperative complications and recurrence rate, which is worthy of clinical application.