摘要
雌激素是类固醇激素,有雌素酮、17β-雌二醇、雌三醇3种形式,通过不同形式的雌激素受体发挥功能。雌激素影响细胞葡萄糖能量代谢,包括葡萄糖转运、糖酵解过程、三羧酸循环和氧化磷酸化作用,同时对葡萄糖能量代谢过程中副产物如甲基乙二醛、活性氧等的产生也具有重要影响。在阿尔茨海默病和肿瘤中都存在葡萄糖能量代谢异常的现象。本文针对阿尔茨海默病和肿瘤就雌激素对葡萄糖能量代谢的调节作用进行综述,以期在预防及治疗相关疾病及开发新药过程中提供新思路。
Estrogen is a steroid hormone, including estrone, 17β-estradiol, estriol, through different forms of estrogen receptors to function. Estrogen affects cell energy metabolism of glucose, including glucose transporter, glycolysis, tricarboxylic acid cycling and oxidative phosphorylation, as well as the by-products such as methylglyoxal, reactive oxygen species in the process of energy metabolism. Abnormal energy metabolism of glucose both exists commonly in Alzheimer＇s Disease and tumors. This article reviews the regulatory role of estrogen on glucose in energy metabolism in Alzheimer＇s Disease and tumors, and offers new ideas for prevention and treatment of related diseases and development of new drugs.
作者
秦春霞
李虹
张帅
张海静
张文生
QIN Chun-xia; LI Hong; ZHANG Shuai; ZHANG Hai-jing; ZHANG Wen-sheng(Beijing Key Laboratory of Traditio 7nal Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China; Engineenng Research Center of Natural Medicine, Ministry of Education, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China; National and Local United Engineering Research Center for Panax Notoginseng Resources Protection and UtsTization Technology, Kunming, Yannan, 650000, China)
出处
《现代生物医学进展》
CAS
2018年第17期3388-3391,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81771152)
中央高校基本科研业务费专项资金项目(2015KJJCA05)
北京市共建项目(2017-01)
关键词
雌激素
葡萄糖能量代谢
阿尔茨海默症
甲基乙二醛
活性氧
Estrogen
Energy metabolism of glucose
Alzheimer＇s Disease
Methylglyoxal
Reactive oxygen species
