数字减影血管造影介入治疗急性颅内动脉栓塞术中应用盐酸替罗非班的疗效分析

Therapeutic effect of tirofiban hydrochloride on interventional treatment of acute intracranial artery embolism by DSA

目的探讨数字减影血管造影(DSA)介入治疗急性颅内动脉栓塞术中应用盐酸替罗非班的价值。方法选取2016年12月至2017年12月顺德第一人民医院收治的54例急性颅内动脉栓塞患者作为研究对象,根据治疗方法对其进行分组,将接受机械取栓联合灌注溶栓药物治疗的27例患者作为观察组,将仅接受药物溶栓治疗的27例患者作为对照组。比较两组患者的临床治疗效果、不良反应发生情况、治疗后血压水平及格拉斯哥预后量表(GOS)评分。结果观察组患者的总输血量、术后动脉瘤直径、出院时间及术后总不良反应发生率、SBP、DBP水平均较对照组低(均P<0.05);观察组患者治疗后GOS评分较对照组高,差异有统计学意义(P<0.05)。结论急性颅内动脉栓塞患者DSA介入治疗中联合盐酸替罗非班治疗效果确切,可明显减少出血量,彻底清除血栓,促进患者快速恢复,并且具有较高安全性,改善患者预后,临床价值较高。

Objective To investigate and analyze the effect of tirofiban hydrochloride in interventional treatment of acute intracranial artery embolism with DSA. Methods Fifty-four patients with acute intracranial arterial embolism admitted to the First People’s Hospital of Shunde from December 2016 to December 2017 were selected as subjects. They were grouped according to treatment,27 patients who received mechanical thrombolysis combined with perfusion thrombolytic therapy were used as observation group and 27 patients who received only drug thrombolytic therapy as control group. The clinical effects and adverse reactions of the two groups were compared, and the blood pressure level and the rascott’s score of the two groups were observed after treatment. Results The total blood transfusion, aneurysm diameter and discharge time in the observation group were significantly lower than those in the control group. 3 the level of SBPnDBP in the observation group was significantly lower than that in the control group after treatment, and the GOS score of the observation group was significantly higher than that of the control group（P〈0.05）. Conclusion DSA combined with tirofiban hydrochloride is effective in the treatment of acute intracranial arterial embolism. It can significantly reduce the amount of bleeding, thoroughly remove thrombus, promote rapid recovery,and has high safety, improve the prognosis of patients with high clinical value.