基于“骨枯髓空”理论从肾论治绝经后骨质疏松症

Discussion on the treatment of postmenopausal osteoporosis from the kidney based on the theory of "bone marrow empty"

目的基于"骨枯髓空"理论为中医理论指导,观察补髓丹加减治疗绝经后骨质疏松症(PMOP)患者的临床疗效。方法选取大连市金州区中医医院2017年1月至2018年4月收治的100例PMOP患者作为研究对象,随机分为分为对照组与观察组,各50例。对照组患者采用阿仑膦酸钠片进行治疗,观察组患者采用阿伦磷酸钠片联合补髓丹加减进行治疗。比较两组患者治疗前后骨密度(BMD)、总骨Ⅰ型前胶原氨基酸延长链(PINP)、N端骨钙素(N-MID)、I型胶原羧基端肽β特殊序列(β-CTX)、临床疗效。结果观察组患者治疗的总有效率高于对照组(P<0.05);治疗后,两组患者的BMD、PINP、N-MID、β-CTX较治疗前均明显改善(均P<0.05);治疗后观察组患者的BMD、PINP、N-MID、β-CTx改善效果优于对照组(均P<0.05)。结论 "骨枯髓空"理论能够指导临床治疗PMOP,补髓丹加减可促进骨代谢,提高临床疗效。

Objective Based on the theory of ＂bone pulp empty space＂ for the guidance of traditional Chinese medicine theory, the clinical efficacy of the treatment of postmenopausal osteoporosis was observed. Methods 100 patients with osteoporosis from January 2017 to April 1818 in Jinzhou District Chinese Medicine Hospital of Dalian were randomly divided into 2 groups. The control group was treated with alendronate sodium tablets, and the treatment group was treated with alendronate sodium tablets combined with medullary Dan. 7 d is a course of treatment and 4 courses of treatment. The BMD, PINP, N-MID, β-CTx and clinical efficacy were observed before and after treatment in the two groups. Results After treatment, the total effective rate of the treatment group was higher than that of the control group（P〈0.05）. The BMD, PINP, N-MID and β-CTx of the two groups were improved before treatment（P〈0.05）. After treatment, the treatment group BMD, The improvement effect of PINP, N-MID and β-CTx was better than that of the control group（P〈0.05）. Conclusion The theory of ＂bone pulp empty space＂ can guide the clinical treatment of postmenopausal osteoporosis, and the addition and subtraction of medullary can promote bone metabolism and improve clinical efficacy.