糖尿病患者血清NGAL、OPG含量与颈动脉斑块性质变化的相关性研究

Correlation of serum NGAL and OPG contents with change of carotid plaques in diabetic patients

目的:探讨糖尿病患者血清NGAL、OPG含量与颈动脉斑块性质变化的相关性。方法:选取在本院收治的2型糖尿病合并颈动脉斑块患者99例作为A组、单纯颈动脉斑块患者86例作为B组。对比两组血清中NGAL、OPG,炎性标志物、脂质代谢指标的含量,采用Pearson检验评估糖尿病合并颈动脉斑块患者血清中NGAL、OPG的含量与颈动脉斑块性质的内在联系。结果:A组血清中NGAL的含量高于B组,OPG的含量低于B组;血清中炎性标志物MMP-9、IL-1β、IL-17、CRP的含量高于B组;血清中脂质代谢指标ApoB、Lp-PLA2的含量高于B组,ApoAⅠ的含量低于B组。相关性分析发现,糖尿病合并颈动脉斑块患者血清中NGAL、OPG含量与炎性标志物、脂质代谢指标的含量直接相关。结论:糖尿病合并颈动脉斑块患者血清中NGAL的含量异常增高,OPG的含量异常降低,与颈动脉斑块稳定性直接相关。

Objective： To investigate the correlation of serum NGAL and OPG contents with the change of carotid plaques in diabetic patients. Methods： A total of 99 patients with type 2 diabetes mellitus complicated with carotid plaque who were treated in Hanzhong Central Hospital between February 2016 and March 2018 were selected as group A, and 86 patients with carotid plaque alone were selected as group B. The serum contents of NGAL, OPG, inflammatory markers and lipid metabolism indexes were compared between the two groups, and Pearson test was used to evaluate the inner correlation of serum NGAL and OPG contents with carotid plaque properties in diabetic patients with carotid plaques. Results： Serum NGAL content of group A was higher than that of group B whereas OPG content was lower than that of group B; serum inflammatory markers MMP-9, IL-1β, IL-17 and CRP contents were higher than those of group B; serum lipid metabolism indexes ApoB and Lp-PLA2 contents were higher than those of group B whereas ApoA Ⅰ content was lower than that of group B. Correlation analysis showed that serum NGAL and OPG contents of patients with diabetes mellitus complicated with carotid plaque were directly correlated with the content of inflammatory markers and lipid metabolism indexes. Conclusions： Serum NGAL content is abnormally increased whereas OPG content is abnormally decreased in patients with diabetes mellitus complicated with carotid plaque, and they are directly correlated with the stability of carotid plaque.