宫颈癌组织中CD24、CD2β分子表达量与癌细胞生长的关系及其潜在治疗价值探究

Relationship of CD24 and CD2β mRNA expression with cancer cell growth in cervical cancer tissues

目的:探讨宫颈癌组织中CD24、CD2β分子表达量与癌细胞生长的关系及其潜在治疗价值探究。方法:宫颈癌患者40例均接受根治性手术治疗,留取癌旁组织、宫颈癌组织标本。对比癌旁组织、宫颈癌组织中CD24、CD2β分子表达量的差异,进一步判断宫颈癌组织中CD24、CD2β分子表达量与增殖、凋亡基因表达量的相关关系。结果:宫颈癌组织中CD24的表达量高于癌旁组织,CD2β的表达量低于癌旁组织。高CD24表达组增殖基因GBP1、eIF4E3 mRNA的表达量低于低CD24表达组,SCD-1、TLR4、HERC4mRNA的表达量高于低CD24表达组;凋亡基因OPCML、DAPK、TSLC1mRNA的表达量低于低CD24表达组,GRIM-19mRNA的表达量高于低CD24表达组。高CD2β表达组增殖基因GBP1、eIF4E3mRNA的表达量高于低CD2β表达组,SCD-1、TLR4、HERC4mRNA的表达量低于低CD2β表达组;凋亡基因OPCML、DAPK、TSLC1mRNA的表达量高于低CD2β表达组,GRIM-19mRNA的表达量低于低CD2β表达组。结论:宫颈癌组织中CD24分子表达量异常增高、CD2β分子表达量异常降低,具体表达量可用于评估宫颈癌细胞的增殖、凋亡活力,间接反映肿瘤病情并有望成为远期治疗方案制定的参考依据。

Objective： To investigate the relationship of CD24 and CD2β mRNA expression with cancer cell growth in cervical cancer tissues. Methods： The cervical cancer tissue samples and tissue samples adjacent to carcinoma were collected from 40 cervical cancer patients with radical surgery. The differences in CD24 and CD2β mRNA expression between adjacent tissues and cervical cancer tissues were compared, and the correlation of CD24 and CD2β mRNA expression with proliferation and apoptosis gene expression was further determined in cervical cancer tissues. Results： CD24 mRNA expression in cervical cancer tissues was higher than that in adjacent tissues, whereas CD2β mRNA expression was lower than that in adjacent tissues. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD24 expression group were lower than those in low CD24 expression group, whereas SCD-1, TLR4 and HERC4 mRNA expression were higher than those in low CD24 expression group; apoptosis genes OPCML, DAPK and TSLC1 mRNA expression in high CD24 expression group were lower than those in low CD24 expression group, whereas GRIM-19 mRNA was higher than that in low CD24 expression group. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD2β expression group were higher than those in low CD2β expression group, whereas SCD-1, TLR4 and HERC4 mRNA expression were lower than those in low CD2β expression group; apoptosis genes OPCML, DAPK and TSLC1 mRNA expression in high CD2β expression group were higher than those in low CD2β expression group, whereas GRIM-19 mRNA was lower than that in low CD2β expression group. Conclusions： CD24 mRNA expression is abnormally increased whereas CD2β mRNA expression is abnormally decreased in cervical cancer tissues. The specific expression levels can be used to evaluate proliferation and apoptosis of cervical cancer cell, which indirectly reflect the tumor condition and are expected to become the reference for long-term therapy development.