孟鲁司特钠联合沙丁胺醇治疗重度支气管哮喘的临床效果及对患者血清ECP、LPO、FeNO水平及肺功能的影响

Curative Efficacy of Montruset Sodium Combined with Albuterol in the Treatment of Severe Bronchial Asthma and Its Effects on the Serum ECP,LPO, FeNO and Lung Function

目的:探讨孟鲁司特钠联合沙丁胺醇治疗重度支气管哮喘的临床效果及对患者血清嗜酸粒细胞阳离子蛋白(ECP)、过氧化脂质/过氧化物酶(LPO)、呼出气一氧化氮(FeNO)水平及肺功能的影响。方法:选择2014年5月到2017年5月我院接诊的重度支气管哮喘患者80例作为研究对象,以随机数表法分为观察组(n=40)和对照组(n=40)。对照组使用沙丁胺醇治疗,观察组在对照组的基础上使用孟鲁司特钠进行治疗。比较两组的临床疗效、治疗前后肺功能、血清ECP、LPO、FeNO水平的变化及不良反应的发生情况。结果:治疗后,观察组临床疗效总有效率为92.20%,明显高于对照组(70.00%,P<0.05);观察组第治疗后秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC水平均明显高于对照组(P<0.05),血清ECP、LPO、FeNO水平均明显低于对照组(P<0.05)。观察组不良反应总发生率为10.00%,显著低于对照组的30.00%(P<0.05)。结论:孟鲁司特钠联合沙丁胺醇治疗重度支气管哮喘患者的临床效果明显优于单用沙丁胺醇治疗,其可有效改善患者的肺功能,可能与其显著降低患者血清ECP、LPO、FeNO水平有关。

Objective： To study the curative efficacy of montruset sodium combined with albuterol in the treatment of severe bronchial asthma and its effects on the serum eosinophil cationic protein（ECP）, lipid peroxidase（LPO）, exhaled nitric oxide（FeNO） and lung function. Methods： 80 cases of patients with severe bronchial asthma who were diagnosed in our hospital from May 2014 to May2017 were selected and divided into the observation group（n=40） and the control group（n=40） the random number table. The control group was treated with salbutamol, and the observation group was treated with montelukast sodium on the basis of control group. The clinical efficacy, changes of lung function, serum ECP, LPO and FeNO levels before and after treatment and the occurrence of adverse reactions were compared between the two groups. Results： After treatment, the total effective rate of observation group was 92.20%, it was significantly higher than that of the control group（70.00%, P〈0.05）. The 1-second forced expiratory volume（FEV1）, forced lung volume（FVC） and FEV1/FVC levels of observation group were significantly higher than those of the control group（P〈0.05）. The serum ECP, LPO and FeNO levels were significantly lower than those of the control group（P〈0.05）. The total incidence of adverse reactions in observation group was 10.00%, it was significantly lower than that of the control group（30.00%, P〈0.05）. Conclusion： Montruset sodium combined with albuterol was more effective than albuterol alone in the treatment of severe bronchial asthma, it could effectively improve the lung function, which may be related to the significant reduce of serum ECP, LPO, FeNO levels.