醒脑静联合古拉定对急性酒精中毒患者血清H_2O_2、SOD、MDA及iNOS水平的影响

Clinical Effect of Xingnaojing Combined with Gluthion on the Serum H_2O_2,SOD, MDA and iNOS Levels of Patients with Acute Alcoholism

目的:探讨醒脑静联合古拉定治疗急性酒精中毒的疗效及对患者血清过氧化氢(H_2O_2)、超氧化物歧化酶(SOD)、丙二醛(MDA)和诱导型一氧化氮合酶(i NOS)水平的影响。方法:选取我院2015年4月至2017年4月收治的80例急性酒精中毒患者,采用随机数字表法分为两组。对照组40例,采用醒脑静治疗;观察组40例,采用醒脑静联合古拉定治疗。记录比较两组症状改善时间,治疗前后肝功能及血清学指标变化,临床疗效与不良反应的发生情况。结果:观察组血压与心率恢复正常及清醒时间均较对照组显著缩短(P<0.01)。与治疗前相比,两组治疗后血清谷酰转肽酶(GGT)、谷草转氨酶(AST)和谷丙转氨酶(ALT)水平均显著下降(P<0.01),且观察组以上指标均显著低于对照组(P<0.01)。治疗4、8 h后,两组血清H_2O_2、MDA、iNOS水平均较治疗前显著下降(P<0.01),血清SOD水平较治疗前显著升高(P<0.01),且观察组以上指标改善较对照组更显著(P<0.01)。观察组治疗后总有效率达97.50%,较对照组(90.00%)略高,但差异无统计学意义(P>0.05)。观察组苏醒后不适率为27.50%,较对照组显著降低(67.50%,P<0.01)。结论:采用醒脑静及古拉定治疗急性酒精中毒患者可更快速、有效消除临床症状,改善肝功能,减少患者不适感,疗效更显著,可能与其有效降低血清MDA、i NOS水平并升高血清SOD水平有关。

Objective： To explore the clinical effect of Xingnaojing combined with Gluthion on the acute alcoholism and influence on the levels of serum hydrogen peroxide（H2O2）, superoxide dismutase（SOD）, malonaldehyde（MDA）, and inducible nitric oxide synthase（i NOS）. Methods： 80 cases of patients with acute alcoholism admitted in our hospital from April 2015 to April 2017 were selected and randomly divided into two groups. 40 patients from the control group were treated with Xingnaojing, while the other 40 patients from the observation group were administrated with a combination of Xingnaojing and Gluthion. The time for improvement in symptoms, the liver function and changes of serological indicators before and after treatment, the clinical effect, and the incidence of adverse reactions were compared between the two groups. Results： The time to resume normal blood pressure, heart rate and consciousness of observation group were significantly shorter than those of the control group（P〈0.01）. The gamma-glutamyl transpeptidase（GGT）, aspartate transaminase（AST）, and alanine transaminase（ALT） levels in both groups were evidently decreased as compared with those before treatment,and the above indexes in observation group were significantly lower than those in control group（P〈0.01）. For both groups, at 4, 8 h after treatment, the levels of H2O2, MDA and i NOS were dipped（P〈0.01） and that of SOD jumped（P〈0.01）, and the improvement in the observation group was larger than that in the control group（P〈0.01）. The overall effective rate of observation group reached 97.50% which was slightly higher than 90.00% of the control group, but showed no statistical difference（P〉0.05）. The proportion of patients feeling uncomfortable after waking up was 27.5% in the observation group, which was much lower than 67.5% in the control group（P〈0.01）.Conclusion： Xingnaojing and Gluthion has better a clinical effect in treating patients with acute alcoholism by eliminating patients symptoms in a faster manner, improving their liver function and reducing their discomfor, which may be associated with its effect in reducing patients＇ serum MDA and i NOS lelves, and increasing their SOD levels as well.