靶向蛋白质-RNA相互作用的HIV抑制剂研究进展

Advances in HIV inhibitors targeting protein-RNA interactions

蛋白质-RNA相互作用是人免疫缺陷病毒(HIV)抑制剂研究的重要靶点,抑制RNA与蛋白质结合是获得具有抗耐药性HIV药物的有效途径。近年来,大量药物的筛选获得了许多蛋白质-RNA相互作用的抑制剂,本文总结了近年来以蛋白质-RNA相互作用为靶点的HIV抑制剂的研究进展。

Protein-RNA interaction is an important target for HIV inhibitors. Inhibiting protein-RNA interaction is an effective way to obtain HIV inhibitors with anti-drug resistance. Recently, a number of drug screening approaches have been used to get HIV inhibitors targeting protein-RNA interactions. This review summarizes the recent progress in this field.