关于CoQ10传递体系的研究进展

Research progress on coenzyme Q10 delivery system

辅酶Q10(CoQ10)是一种广泛存在于生物体中的重要脂溶性类维生素物质。本文主要从CoQ10的生理活性、体内的新陈代谢以及不同的保护和传递手段三个方面进行展开。生理活性方面,CoQ10可以参与线粒体膜内的电子传递,控制细胞的氧化还原状态并且减少活性氧的形成。在生理功能方面,CoQ10可以参与机体的新陈代谢,而且对于抗炎,增强人体免疫力,治疗肾衰竭、心血管疾病等方面都有一定效果。目前常用的CoQ10的传递体系有固体颗粒、乳液、微胶囊、脂质体、包合物等。总体来说,CoQ10是一种潜力巨大的功能性成分,对于多种疾病都有预防和治疗功能,在食品、医药等各个领域都有广泛应用,本文希望对利用不同的传递体系来提高CoQ10理化稳定性和生物利用率提供一定的理论基础和参考。

Coenzyme QIO （CoQlO） is an important fat-soluble vitamin-like substance widely present in living organisms. This study mainly focuses on three areas of Coenzyme; physiological activity, metabolism in human body and its protection and transmission methods. In terms of physiological activity, CoQIO can participate in electron transport in the mitochondrial membrane, control the redox state of cells and reduce the formation of reactive oxygen species. In terms of physiological functions, CoQIO can participate in metabolism of human body and has certain effects on anti-inflammatory, enhancing human immunity, as well as being helpful in kidney failure and cardiovascular diseases. At present, commonly used CoQIO delivery system includes solid particles, emulsions, microcapsules, liposomes, and clathrates. In general, CoQlO is a functional component with great potential. It has preventive and therapeutic functions for various diseases. It is widely used in various fields such as food and medicine. This paper provides some theoretical basis and reference on improving physical and chemical stability and biovailability of CoQIO by using different delivery systems.