亲水改性剂表面修饰纳米羟基磷灰石对其分散性的影响

Effect of Surface Modification of Nano-Hydroxyapatite on the Dispersion of Hydrophilic Modifier

纳米羟基磷灰石(n HA)的分散性差,导致制备的n HA/聚乳酸(PLA)生物工程材料中存在团聚的大颗粒n HA,对复合材料的性能产生不利的影响。实验中分别用多巴胺(DA)、聚乙二醇、壳聚糖等亲水改性剂对n HA进行改性效果分析,发现DA可以改善n HA的分散性;同时发现DA可以氧化自聚在n HA表面生成聚多巴胺(PDA)纳米层,且生物活性良好。用DA对n HA进行表面修饰改性,通过红外光谱、X射线衍射、扫描电镜等分析其改性效果,结果表明,DA可以改善n HA的分散性,当DA的用量达到6%、8%时改性效果较好,改性后的n HA颗粒在PLA基体中的团聚现象减弱,实现了较好的分散。

The poor dispersibility of nano-hydroxyapatite（nHA） resulted in the agglomeration of large particles of nHA in the prepared bio-engineered nHA/PLA materials,which had an adverse effect on the properties of the composites. In the experiment,the modification of nHA with dopamine（DA）,polyethylene glycol,chitosan and other hydrophilic modifiers was analyzed. It is found that DA could improve the dispersibility of nHA. At the same time,it is found that DA could be oxidized in nHA surface and polydopamine（PDA） nano-layer with good biological activity is generated. Therefore,in this experiment,DA was used to modify the surface of nHA. The results of the modification were analyzed by infrared spectroscopy,X-ray diffraction and scanning electron microscopy. The results show that DA can improve the dispersibility of nHA. When the dosage of DA reaches 6%,8%,the better modification effect can be achieved. The agglomeration of the modified nHA particles in the PLA matrix is weakened and achieved better dispersion. Using DA as surface modification modifier for nHA,the dispersion of modified n HA in the matrix is significantly improved.