纳米羟基磷灰石/聚乳酸多孔生物工程材料的制备与性能

Preparation and Properties of Nano-Hydroxyapatite/Polylactic Acid Porous Bioengineering Materials

纳米羟基磷灰石(n HA)/聚乳酸(PLA)生物工程材料可作为骨的替代材料,在医学上有较大的应用价值。n HA是骨组织的主要成分,有良好的生物活性,可作为骨组织工程材料的填充物;而PLA在生物体内可完全降解,有良好的生物相容性。文中通过制备多孔n HA/PLA复合材料,探讨最佳的n HA添加量以及高效的致孔方法。实验发现,n HA分散在PLA的过程中,通过乙醇溶剂的引入制备出多孔复合材料,制备方法简单高效无毒,所得样品有较好的孔结构;而XRD测试结果表明n HA可以促进PLA的结晶,为PLA的结晶研究提供了借鉴。同时,观察SEM图发现,实验中以m(n HA)∶m(PLA)≤3∶10比例改性为宜,而最佳的添加比例为m(HA)∶m(PLA)=1∶10,此时制得的样品具有较好的成孔性。

Nano-hydroxyapatite（nHA）/polylactic acid（PLA） bio-engineering materials can be used as alternative material for bone,which has great application in medicine. Nano-hydroxyapatite is main component of bone tissue,has good biological activity,can be used as filler for bone tissue engineering materials; and PLA can be completely degraded in vivo,with good biocompatibility. In this paper,porous nHA/PLA composites were prepared to explore the best n HA addition and efficient method of forming holes. It is found that the porous composite material was prepared by the introduction of ethanol solvent during the dispersion of nHA in PLA. The preparation method is simple,efficient and non-toxic,and the obtained sample has better pore structure. The results of XRD show that nHA could promote the crystallization of PLA,which provides a reference for the crystallization of PLA. At the same time,observing the SEM images found that the experiment to m（nHA） ∶ m（PLA） ≤3∶ 10 modification is appropriate. And the best addition ratio of m（HA） ∶ m（PLA） = 1∶ 10,the sample prepared at this mass ratio has better porosity.