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先天性心脏病儿童预防接种安全性分析 被引量:6

Safety of vaccination in children with congenital heart disease
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摘要 目的探讨先天性心脏病儿童预防接种的安全性。方法选取2013年7月至2017年7月于清华大学第一附属医院进行预防接种的先天性心脏病患儿共69例,以当日相同社区、同一性别、接种同类疫苗儿童作为安全性观察对照样本,进行疫苗接种后安全性主动监测的调查分析。结果 69例先天性心脏病患儿中,15例手术治疗后愈合以及54例未手术自愈或未自愈患儿,均于不同时期进行疫苗接种后,仅8例患儿出现不良反应,其中5例经判断与疫苗接种无关,且8例接种者均在24 h内恢复正常。与对照组相比,两组反应发生率差异无统计学意义(P>0.05)。结论先天性心脏病儿童在心功能正常及机体健康情况下进行预防接种,不良反应发生率较低,安全性较高。 Objective To investigate the safety of vaccination in children with congenital heart disease. Methods A total of 69 children with congenital heart disease who received vaccination in The First Hospital Affiliated to Tsinghua University during July 2013 to July 2017 were subjected to the active monitoring of safety after vaccination, using those from the same communities, of the same genders, who received the same vaccines on the same dates as control. Results In the 69 children including 15 ones healed after surgery and 54 ones self-healed without surgery or unhealed, who were vaccinated at different times, only 8 cases of adverse events appeared, including 5 cases unrelated to the vaccination, all of which recovered to normal within 24 h. The incidence of adverse reactions showed no significant difference with that in control group (P 〉 0. 05). Conclusion The incidence of adverse reaction in children with congenital heart disease with normal heart function and body health were low, indicating a high safety.
作者 郑东旖 刘兆秋 马松 张爱玲 张文静 时念民 ZHENG Dong-yi;LIU Zhao-qiu;MA Song;ZHANG Ai-ling;ZHANG Wen-jing;SHI Nian-min(The First Hospital Affiliated to Tsinghua University,Beijing 100016,China)
出处 《中国生物制品学杂志》 CAS CSCD 2018年第10期1126-1129,共4页 Chinese Journal of Biologicals
关键词 先天性心脏病 儿童 预防接种 安全性 Congenital heart disease Children Vaccination Safety
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