NERD患者食管动力、24 h酸反流及伴发情绪因素动态测定值与年龄的相关性

HRM,the dynamically monitoring value of 24-hour gastric acid reflux and associated emotion factors:Relativity analysis with NERD patient's age

目的通过对不同年龄段NERD患者高分辨率食管测压、24 h食管胃酸pH监测及HAMA和HAMD他评量表评定结果分析,总结其发病特点,以期为临床NERD患者提供更精准治疗。方法选取具有反酸、胃灼热症状的NERD患者98例,按年龄段随机分为3组,A组(青年组)31例,B组(中年组)34例,C组(老年组)33例,通过观察LES静息压力、食管异常运动百分比、酸反流次数、反流指数、DeMeester积分及HAMA/HAMD评分等指标,评价不同年龄段NERD患者的发病特点。结果 LES静息压力、食管异常运动百分比、反流指数(%)与DeMeester积分方面,B组与C组相比,具有统计学差异(P<0.05);A组与B组,A组与C组相比,P>0.05。酸反流次数方面,A,B,C三组,组间两两比较,差异均无统计学意义(P>0.05)。HAMA/HAMD他评量表评分,A组与B组、B组与C组,均P<0.05,差异具有统计学意义,A组与C组相比,P>0.05,差异无统计学意义。结论不同年龄段NERD患者发病机制及特点存在不同的趋向性。

Objective Through analysing the results of NERD patients in HRM,24-hour gastric acid pHmonitoring and HAMA/HAMD scale at different ages,to summarize the pathogenesis,in order to provide moreaccurate treatment clinically for NERD. Methods The 98 NERD patients with anti-acid and heartburn symptoms,randomly were divided into 3 groups according to age i.e,group,A、B and C. By observing the resting pressure ofLES,percentage of esophageal abnormal movement,acid reflux frequency,reflux index,DeMeester and HAMA/HAMD,the characteristics of patients at different ages were evaluated. Results In resting pressure of LES,percentage of esophageal abnormal movement,acid reflux frequency,DeMeester,there was a statistical differencebetween group B and group C （P〈0.05）,but not between group A and group B,as well as group A and group C（P〉0.05）. In reflux index,between A,B,and C there were no statistically difference （P〉0.05）. In HAMA/HAMD,between group A and B,as well as group B and C there were statistically difference（P〈0.05）,but group A had nostatistically difference compared with group C（P〉0.05）. Conclusion The pathogenesis and characteristics of NERDpatients at different age have different tendencies.