阿戈美拉汀对首发抑郁症及性功能障碍的疗效

Effects of agomelatine on depression symptoms and sexual function of patients with first-episode depression

目的观察阿戈美拉汀对首发抑郁症及性功能障碍的疗效。方法将90例首发抑郁患者随机分为两组,各45例,研究组予以阿戈美拉汀治疗6周,对照组予以氟西汀治疗6周,于治疗前,治疗1、2、4、6周末用汉密尔顿抑郁量表(HAMD-17)、亚利桑那性体验量表(ASEX)评定疗效和性功能,6周末用治疗副反应量表(TESS)评定药物的安全性。结果抑郁症状有效率研究组为86.67%,对照组为84.44%,两组差异无统计学意义(P>0.05);1、2周末,研究组HAMD-17评分低于对照组(P<0.05);两组TESS评分比较差异无统计学意义(P>0.05)。治疗后研究组ASEX评分及性功能障碍发生率均低于对照组(P<0.05)。结论阿戈美拉汀对首发抑郁症疗效较好、同时对抑郁患者的性功能有一定的改善作用。

Objective To observe the effects of agomelatine on depression symptoms and sexual function of patients with first-episode depression. Methods A total of 90 patients with first-episode depression was randomly divided into research group（45 cases treated with agomelatine）and control group（45 cases treated with fluoxetine）for 6 weeks. HAMD-17 was used to evaluate the clinical efficacy before treatment and at the 1 st,2 nd,4 th and 6 th weekend of treatment,the ASEX to assess sexual function,and the adverse reactions were assessed with the TESS at the 6 th weekend of treatment. Results The effective rate of the research group was 86.67%,while the control group was 84.44%. There was no statistical significance between the two groups（P〈0.05）. The total score of HAMD-17 in the research group were lower than that in the control group at the 1 st and 2 nd weekend of treatment（P〈0.05）. At the 6 th weekend of treatment,there was no significant difference in the TESS scores of the two groups（P〈0.05）. ASEX score after treatment and the incidence of sexual dysfunction in the research were lower than those in the control group（P〈0.05）. Conclusion Argomeladine has a relatively good effect on the initial depression and has a certain effect on sexual function.