摘要
We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.
We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.
基金
supported by the National Key R&D Program of China (No. 2017YFA0208100)
the National Natural Science Foundation of China (Nos. 21778057, 21502201 and 21420102003)
Beijing Natural Science Foundation (No. 2162049)
Young Elite Scientist Sponsorship Program by CAST (No. 2015QNRC001)
Chinese Academy of Sciences
