摘要
More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared （NIR） photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin （BSA）-reduced and stabilized MnO2 nanoparticles （BSA-MnO2 NPs） with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.
More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared （NIR） photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin （BSA）-reduced and stabilized MnO2 nanoparticles （BSA-MnO2 NPs） with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.
基金
financial support from the following sources: National Natural Science Foundation of China (No. 81601632)
the Natural Science Foundation of Jiangsu Province (No. SBK2016041233)
the Fundamental Research Funds for Central Universities(No. 021314380067)
Thousand Talents Program for Young Researchers, NIH (No. 1R21CA190024-01)
DOD (No. W81XWH-12-1-0414)
Houston Methodist Research Institute
