茶色素和山楂提取物组合减肥功能评价

Evaluation of Slimming Function of Combination of Tea Pigment and Hawthorn Extract

目的评价茶色素和山楂提取物组合对营养性肥胖大鼠的减肥作用。方法采用高热量食物喂养制备肥胖大鼠模型,设对照组、模型组、茶色素和山楂提取物组合高剂量组(相当于人用推荐量的20倍)、低剂量组(相当于人用推荐量的5倍)。每周记录给食量、剩食量,称体质量1次。给药6周后,称体质量,麻醉,解剖取肾周围脂肪、睾丸周围脂肪,并称定质量,计算脂/体比。结果茶色素和山楂提取物组合高、低剂量与模型组比较,进食量无明显差异,且均能减轻模型大鼠体质量,减少体内脂肪质量(睾丸周围脂肪垫、肾周围脂肪垫),降低脂/体比,其中高剂量组尤为显著(P<0.05)。结论茶色素和山楂提取物组合对营养性肥胖大鼠具有减肥作用。

OBJECTIVE To evaluate the effect of combination of tea pigment and hawthorn extract on reducing weight of nutritional obesity rats. METHODS Obese model was induced by high calorie forage. The rats were divided into control group, model group, tea pigment and hawthorn extract combination high dose group（equivalent to 20 times human recommendation）, low dose group（equivalent to 5 times human recommendation）. Recorded quantity of forage given and surplused weekly. Weighed once a week. After drug delivery for 6 weeks, weighed, anesthetized, laparotomized to take fat around testis and kidney and then weighed these fat, calculated fat/body weight ratio. RESULTS Compared with the model group, the high and low dose group of tea pigment and hawthorn extract had no significant difference in food intake, and all dose groups could reduce weight, body fat around testis and kidney, and fat/body weight ratio, significantly in the high dose group（P〈0.05）. CONCLUSION Combination of tea pigment and hawthorn extract has effect on reducing weight of nutritional obesity rats.