辛伐他汀联合雷公藤多苷对糖尿病肾病的疗效研究

Therapeutic effect of simvastatin combined with Tripterygium on patients with diabetic nephropathy

目的:探讨辛伐他汀联合雷公藤多苷对糖尿病肾病的治疗效果。方法:选取我院收治的98例糖尿病肾病患者,按照随机数字表法均分为两组各49例:辛伐他汀组给予辛伐他汀治疗,联合治疗组在辛伐他汀治疗基础上给予雷公藤多苷,疗程3个月。观察两组总有效率、24 h尿蛋白定量(24 h UTP)、超敏C反应蛋白(hs-CRP)水平、肾功能、血脂水平以及不良反应。结果:治疗3个月后,联合治疗组总有效率为91. 9%,明显高于辛伐他汀组的75. 5%(P <0. 05);两组24 h UTP和hs-CRP水平较治疗前明显降低(P <0. 05),治疗1、2、3个月后联合治疗组比辛伐他汀组降低更明显(P <0. 05);两组患者血肌酐(SCr)、尿素氮(BUN)、总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)水平等较治疗前明显降低(P <0. 05),联合治疗组比辛伐他汀组降低更显著(P <0. 05);两组不良反应发生率差异无统计学意义(P> 0. 05)。结论:辛伐他汀联合雷公藤多苷对糖尿病肾病的疗效显著,可有效改善肾功能,降低血脂和hs-CRP水平,安全可靠,值得推广应用。

Objective： To explore the therapeutic effect of simvastatin combined with Tripterygium on patients with diabetic nephropathy. Methods： Ninety-eight patients with diabetic nephropathy treated in our hospital were divided into simvastatin group（n = 49） and combination group（n = 49） by random number table method. The simvastatin group received simvastatin while the combination group was treated with Tripterygium glycosides in addition to simvastatin. After 3-month treatment,the total effective rate,24 h urinary total protein（24 h UTP）,hypersensitive C-reactive protein（hs-CRP）,renal function,blood lipid and adverse reactions were observed.Results： After treatment for 3 months,the total effective rate（91. 9%） in the combination group was much higher than that 75. 5% of the simvastatin group（P 〈 0. 05）. The levels of 24 h UTP and hs-CRP in the two groups were much lower than those before the treatment（P 〈 0. 05）,while the levels in combination group were much lower than those in simvastatin group after treatment for 1 month,2 months and 3 months（P 〈 0. 05）. The levels of SCr,BUN,TC,TG and LDL-C in the two groups were significantly decreased compared with those before the treatment（P 〈 0. 05）. Compared with simvastatin group,the levels in combination group were decreased more significantly.And there was no statistically significant difference in adverse reactions between the two groups（P 〉 0. 05）.Conclusion： The treatment of simvastatin combined with Tripterygium glycosides is effective for patients with diabetic nephropathy,which can improve the renal function and reduce the levels of serum lipid and hs-CRP. It is safe,reliable and worthy of clinical application.