嗜酸粒细胞增多型慢性阻塞性肺疾病急性加重相关生物标记物的研究进展

Progress of related biomarkers of eosinophilia phenotype of acute exacerbation of chronic obstructivepulmonary disease

慢性阻塞性肺疾病（COPD）是一种常见的可以预防和治疗的疾病，以持续呼吸症状和气流受限为特征，其致残率和病死率很高。随着慢性阻塞性肺疾病急性加重（AECOPD）表型研究的深入，发现嗜酸粒细胞增多型具有独特的临床特点，对预测未来急性加重、评估疗效和预后有重大作用。目前，国内外指南中并未明确指出可对AECOPD炎症表型进行分型的生物标记物。本综述旨在对嗜酸粒细胞增多型AECOPD临床最常用的三种标记物的研究现况、发展趋势及前景进行阐述。

Chronic obstructive pulmonary disease （COPD） is a common disease that can be prevented and treated. It is characterized by persistent respiratory symptoms and airflow limitation, with high morbidity and mortality. With the study of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） phenotypes deeply, it is found that eosinophilia phenotype of AECOPD has unique clinical characteristics, which is of great significance to predict future acute exacerbation, evaluate the curative effect and prognosis. At present, the domestic and foreign guidelines have not clearly pointed out the biomarkers that can be typed in the AECOPD inflammatory phenotypes. This review aims to explain the current status, trends and prospects of the three most commonly used biomarkers of eosinophilia phenotype of AECOPD