2017年登封市儿童青少年脑膜炎奈瑟球菌带菌抽样调查

Sampling survey of Neisseria meningitidis of children and adolescents in Dengfeng City, 2017

目的了解河南省登封市儿童青少年中脑膜炎奈瑟菌(Nm)的菌群分布特征与变迁趋势,为流行性脑脊髓膜炎(流脑)的防控工作提供有效的信息。方法按照分层分组随机抽样的方法,将调查对象分为7个年龄组,每个采样对象采集1支咽拭子,共采集210份样本,运用细菌培养和实时荧光(real-time PCR)的方法对标本进行菌群的鉴定。结果儿童青少年中检出脑膜炎奈瑟菌47株,儿童青少年Nm的带菌率为22.38%;血清分群中,C群占51%,W135占群21%,Y群占15%,B群占2%,X群占4%,不可分群的占6%。0～6岁带菌率为0,14～19岁的带菌率最高为90.0%。结论登封市儿童青少年中脑膜炎奈瑟菌带菌率较高,菌群分布广,存在流行性脑脊髓膜炎的暴发风险。

ObjectiveTo understand the distribution characteristics and changing trends of Neisseria meningitidis（Nm） in healthy people in Dengfeng City, Henan Province, so as to provide the effective information for the prevention and con-trol of epidemic meningitis.MethodsAccording to the stratified and random sampling method, the subjects were divided in-to 7 age groups. One swab was collected from each sample subject and 210 samples were collected. The bacterial culture andreal-time fluorescence PCR were used for the identification of the flora of the specimen.ResultsA total of 47 Nm strainswere detected. The prevalence rate of Nm was 22.38% in the healthy population. Among the serum-gruppierung, 51% in Cgroup, 21% in W135 group, 15% in Y group, 2% in B group, 4% in X group, and 6% of inseparable groups. In the age groups,the carrier rate was 0 for the 0-6 year age group, and the highest carrier rate was in the 14-19-year age group（90%）.ConclusionThe prevalence of Nm in Dengfeng City is high, the distribution of bacterial population is extensive, the structure iscomplex, and there is a risk of outbreak of epidemic meningitis.