桂枝加龙骨牡蛎汤联合西药治疗2型糖尿病合并焦虑随机平行对照研究

Randomized Controlled Parallel Study of Guizhi and Longgu Muli Decoction(桂枝加龙骨牡蛎汤) combined with Western Medicine in the Treatment of Type 2 Diabetes Mellitus with Anxiety

[目的]观察桂枝加龙骨牡蛎汤联合西药治疗2型糖尿病合并焦虑疗效。[方法]使用随机平行对照方法,将120例住院及门诊患者按随机数字表法随机分为两组;保持原降糖用药。对照组60例艾司唑仑,1～2mg/次,3次/d。治疗组60例桂枝加龙骨牡蛎汤(桂枝10g,白芍、姜~生各15g,甘草10g,大枣12枚,龙骨~生、牡蛎~生各30g,柴胡10g,黄精、白术各15g),水煎300mL,1剂/d,2次/d;艾司唑仑治疗同对照组。连续治疗2周为1疗程。观测临床表现、空腹血糖、餐后2h血糖、焦虑评分、不良反应。治疗1疗程(2周),判定疗效。[结果]治疗组痊愈40例,显效15例,有效4例,无效2例,总有效率96.67%;对照组痊愈30例,显效15例,有效7例,无效8例,总有效率86.67%;临床疗效治疗组优于对照组(P<0.05)。空腹血糖、餐后2h血糖、果糖胺、焦虑评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]桂枝加龙骨牡蛎汤联合西药治疗2型糖尿病合并焦虑,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the effect of Guizhi and Longgu Muli decoction combined with western medicine on type 2 diabetes mellitus with anxiety. [Methods] 120 inpatients and outpatients were randomly divided into two groups according to the method of random number table by using random parallel control method. In the control group, 60 cases were treated with isalpride, 1 to 2 mg/times, and 3 times/d. 60 cases in the treatment group were decocted with Guizhi and Longgu Muli decoction（Guizhi 10 g, Baishao, Shengjiang each 15 g, Gancao 10 g, Dazao 12, Shenglonggu, Shengmuli each 30 g, Chaihu 10 g, Huangjing, Baizhu each 15 g）, decoction 300 mL, 1 dose per day, 2 times per day; the control group was treated with western medicine for pain. Continuous treatment for 2 weeks was 1 courses. Clinical symptoms, fasting blood glucose, postprandial 2 H blood glucose, anxiety score and adverse reactions were observed. The course of treatment was 1 weeks（2 weeks）, and the curative effect was judged. [Results] In the treatment group, 40 cases were cured, 15 cases were markedly improved, 4 cases were progressive, 2 cases were ineffective, the total effective rate was 96.67%; in the control group, 30 cases were cured, 15 cases were markedly improved, 7 cases were progressive, 8 cases were ineffective, the total effective rate was 86.67%; the clinical curative effect of the treatment group was better than that of the control group（P〈0.05）. The fasting blood glucose, postprandial blood glucose, fructosamine and anxiety score were improved in both groups（P〈0.01）, and the improvement in the treatment group was better than that in the control group（P〈0.01）. [Conclusion] Guizhi and Longgu Muli decoction combined with western medicine in the treatment of type 2 diabetes mellitus with anxiety has satisfactory curative effect without serious adverse reactions and is worth popularizing.