附子与天花粉配伍对小鼠的亚急性毒性研究

Studies on Subacute Toxicity of Decoction from Monkshood and Trichosanthes Root in Mice

目的:观察附子、天花粉、附子与天花粉配伍对小鼠的亚急性毒性,以评价附子与天花粉配伍的安全性。方法:给小鼠灌服586 mg/kg的药物,对照组给以等剂量生理盐水,观察小鼠中毒症状,记录小鼠的死亡数、体重、脏器系数。结果:给药组各组与对照组比体重增重差异具有统计学意义(P<0. 05);给药组各组的心、肝、脾、肺的脏器指数与对照组比差异无统计学意义(P>0. 05),第8组(附子单煎0 min)肾脏系数与对照组比差异具有统计学意义(P<0. 05)。结论:附子与天花粉配伍并未增加其相对的毒性,若比较第8组,其合煎毒性较附子单煎肾毒性还有所减小。

Objective Observant the Subacute toxicity of decoction from Monkshood and Trichosanthes root , and evaluate their safety. Methods The 586 mg/kg drugs was taken to the mice, and the control group was given equal dose of physiological saline, Observat the symptoms of poisoning in mice, recorded the number of death, weight, and organ coefficient of mice. Results The difference of weight gain between the administration group and the control group has statistical significance （ P 〈 0.05 ） , The visceral index of heart, liver, spleen and lung in the drug group has not statistical significance compared with the control group （ P 〉 0.05 ）. The renal coefficient of the eighth group has statistical significance compared with the control group （ P 〈 0.05 ）. Conclusion The compatibility of aconite and Trichosanthes root did not increase the relative toxicity, Compared with the eighth group, the toxicity of the Single decoction from Monkshood was less in kidney.