经颅磁刺激联合丙戊酸钠注射液治疗癫痫持续状态的效果分析

Effects of Transcranial Magnetic Stimulation Combined with Sodium Valproate Injection in the Treatment of Status Epilepticus

目的:探讨经颅磁刺激(transcranial magnetic stimulate,TMS)联合丙戊酸钠注射液治疗癫痫持续状态的效果。方法:选择2014年8月到2017年8月在我院诊治的癫痫持续状态患者79例,根据治疗方法的不同分为观察组40例与对照组39例。对照组给予丙戊酸钠注射液治疗,观察组在对照组治疗的基础上给予经颅磁刺激治疗,两组均治疗1个月,比较其临床总有效率、治疗期间不良反应的发生情况及治疗前后低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)水平、行为能力评分、被动肌动力评分及主动肌动力评分的变化。结果:观察组与对照组总有效率分别为97.5%和84.6%,观察组显著高于对照组(P<0.05)。治疗期间,观察组食欲下降、恶心呕吐、嗜睡、头痛等不良反应发生率为10.0%,对照组为12.8%,两组对比无显著差异(P>0.05)。治疗后,观察组TG、TC与LDL-C水平显著低于对照组(P<0.05),两组HDL-C含量对比无显著差异(P>0.05)。治疗后,观察组的行为能力评分、被动肌动力评分、主动肌动力评分都高于对照组(P<0.05)。结论:经颅磁刺激联合丙戊酸钠注射液治疗癫痫持续状态能显著提高治疗效果,改善患者的神经行为功能,且不会影响患者的血脂水平与增加不良反应。

Objective： To explore the effects of transcranial magnetic stimulation combined with valproate injection in the treatment of status epilepticus. Methods： We selected 79 patients with status epilepticus who were diagnosed and treated in our hospital from August 2014 to August 2017. According to the different treatment methods, 40 patients were divided into observation group and 39 control groups. The control group was treated with sodium valproate injection, while the observation group was treated with transcranial magnetic stimulation on the basis of the control group. The two groups were treated for 1 months. Comparing the clinical total effective rate, occurrence of adverse reactions during treatment, and before and after treatment [All initial English abbreviations in the thesis must be supplemented with full English names] Low-density lipoprotein cholesterol（LDL-C）, high-density lipoprotein cholesterol（ Changes in HDL-C, total cholesterol（TC）, triglyceride（TG） levels, behavioral ability scores, passive muscle force scores, and active muscle force scores. Results： The total effective rate of the observation group and the control group were 97.5% and 84.6% respectively, and the observation group was significantly higher than that of the control group（P〈0.05）. During the treatment, the incidence of adverse reactions such as headache, drowsiness, nausea and decreased appetite in the observation group was 10%, while that in the control group was 12.8%. There was no significant difference compared between the two groups（P0.05）. After treatment, the levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group（P0.05）. There was no significant difference in the HDL-C levels between the two groups（P0.05）. After treatment, the scores of the active muscle tension, the passive muscle tension and the behavioral ability of the observation group were significantly higher than those of the control group（P〈0.05）. Conclusion：Transcranial magnetic stimulation combined with sodium valproate injection in the treatment of status epilepticus can significantly improve the therapeutic effect, improve the patient＇s neurobehavioral function, and will not affect the patient＇s blood lipid levels and increase adverse reactions.