加兰他敏联合复方海蛇胶囊治疗阿尔茨海默病早发型痴呆的临床疗效及对血清IL-6、IL-8、TNF-α水平的影响

Clinical Efficacy of Galantamine combined with Fufang Haishe Capsule in the Treatment of Early-Onset Alzheimer's Disease Dementia and the Effect on the Serum IL-6,IL-8,TNF-α Levels

目的:观察加兰他敏联合复方海蛇胶囊治疗阿尔茨海默病早发型痴呆的临床效果及对血清白细胞介素-6、8(IL-6、IL-8)和肿瘤坏死因子-α(TNF-α)水平的影响。方法:选择我院2014年9月～2016年9月收治的96例阿尔茨海默病早发型痴呆患者,按照治疗方式分为对照组和实验组,每组48例。对照组予以加兰他敏治疗,实验组在对照组基础上加用复方海蛇胶囊治疗,观察和比较两组的临床疗效,治疗前后血清IL-6、IL-8、TNF-α、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、简易智力状态评分(MMSE)、老年痴呆患者生活质量量表(QOL-AD)的变化以及不良反应的发生情况。结果:治疗后,实验组有效率显著高于对照组[93.75%vs 77.08%](P<0.05)。治疗前,两组血清IL-6、IL-8、TNF-α、FT3、FT4、MMSE、QOL-AD比较差异无统计学意义(P>0.05);治疗后,两组血清IL-6、IL-8、TNF-α水平均较治疗前显著降低,且实验组低于对照组(P<0.05);两组FT3、FT4、MMSE、QOL-AD均较治疗前明显上升,且实验组显著高于对照组(P<0.05)。两组不良反应的发生情况比较差异无统计学意义(P>0.05)。结论:加兰他敏联合复方海蛇胶囊治疗阿尔茨海默病早发型痴呆的临床效果优于加兰他敏单药治疗,其能够降低患者血清IL-6、IL-8及TNF-α浓度,并能提高血清甲状腺激素的水平。

Objective： To observe the clinical efficacy of galantamine combined with fufang haishe capsule in the treatment of early-onset Alzheimer＇s disease dementia and the effect on the serum interleukin-6, 8（IL-6, IL-8）, tumor necrosis factor-α（TNF-α）levels. Methods： 96 cases of patients with early-onset alzheimer＇s disease dementia from September 2014 to September 2016 were selected and divided into the control group and the experimental group according to the treatment. The control group was treated by galantamine, while the experimental group（n=48） was treated on the by Fufang Haishe capsule based on the control group. The clinical curative effect, changes of serum levels of IL-6, IL-8, TNF-α, free three iodine thyroid original glycine（FT3） and free thyroxine（FT4）,marks,mini-mental state examination（MMSE）, alzheimer＇s patients quality of life scale（QOL-AD） before and after treatment and the occurrence of adverse reactions were observed and compared between two groups. Results： After treatment, the effective rate of experimental group was significantly higher than that of the control group [93.75% vs 77.08%]（P0.05）; the serum levels of IL-6, IL-8,TNF-α of both groups were significantly reduced than those before treatment, which were obviously lower than those of the control group（P0.05）; the FT3, FT4, MMSE, QOL-AD of both groups were significantly rised than before treatment, which were significantly higher in the experimental group were significantly higher than those of the control group（P0.05）. No significant difference was found in the occurrence of adverse reactions between two groups（P0.05）. Conclusion： Galantamine combined with Fufang Haishe capsule was more effective than those of galantamine monotherapy, in the treatment of early-onset alzheimer＇s disease dementia, it could reduce the serum levels of IL-6, IL-8 and TNF-α, and improve the levels of serum thyroid hormones.