他克莫司治疗眼部疾病的研究进展

Tacrolimus for the treatment of eye diseases

他克莫司（Tacrolimus，又称FK506）是一种新型免疫抑制剂，主要用于肝脏移植、特应性皮炎等疾病。在眼部疾病中，他克莫司滴眼剂对免疫原性炎症性疾病（如春季角结膜炎、难治性过敏性结膜炎、自身免疫性结膜炎等免疫性角结膜炎）有效。随着研究的进展，他克莫司滴眼剂逐步应用于治疗移植物抗宿主病相关干眼、角膜移植排斥反应，他克莫司口服或玻璃体注射治疗难治性葡萄膜炎等。

Tacrolimus （FKS06） , a novel immunosuppressant, has been used in liver transplanta- tion and atopie dermatitis since it was discovered in 1984. In the field of eye diseases, eyedrops of tacroli- mus has shown efficacy in immune-based inflammatory disorders （such as immune conjunctival and corneal diseases including vernal keratoconjunctivitis, refractory allergic conjunctivitis and autoimmune conjunctivi- tis）. As research developed, eyedrops of tacrolimus has been widely applied in graft-versus-host disease, corneal graft rejection, and oral or intravitreal injection of tacrolimus applied in refractory uveitis.