普罗布考联合阿托伐他汀对大动脉源性脑梗死患者血流动力学及血脂的影响

Influence of probucol combined atorvastatin on hemodynamics and blood lipids in patients with large artery cerebral infarction

目的:分析普罗布考联合阿托伐他汀对大动脉源性脑梗死患者血流动力学及血脂的影响。方法:92例大动脉源性脑梗死患者被随机均分为阿托伐他汀组与联合治疗组(阿托伐他汀联合普罗布考治疗)。治疗6个月,比较两组临床疗效,治疗前后血脂、炎性因子水平,颅内动脉血流动力学指标等变化。结果:治疗6个月后,与阿托伐他汀组比较,联合治疗组治疗总有效率(69.57%比89.13%P=0.020)显著升高;TC [(4.57±0.82)mmol/L比(3.23±0.71)mmol/L]、TG [(1.37±0.45)mmol/L比(1.02±0.34)mmol/L]、LDL-C [(2.52±0.83)mmol/L比(1.50±0.54)mmol/L]、氧化修饰低密度脂蛋白[ox-LDL,(78.36±14.05)mg/L比(58.37±12.00)mg/L]及左右大脑中动脉搏动指数(PI)[左:(0.84±0.25)比(0.74±0.14),右:(0.84±0.23)比(0.74±0.16)]、炎性因子水平明显下降;左右大脑中动脉收缩期血流速度(Vs)[左:(87.45±15.58)cm/s比(95.48±18.34)cm/s,右:(89.27±14.36)cm/s比(96.18±14.03)cm/s]、平均血流速度(Vm)[左:(60.90±16.19)cm/s比(76.19±17.40)cm/s,右:(62.08±17.23)cm/s比(91.38±19.26)cm/s]显著上升(P<0.05或<0.01)。两组药物不良反应率无显著差异(P=1.000)。结论:普罗布考联合阿托伐他汀治疗大动脉源性脑梗死疗效明显优于单纯阿托伐他汀治疗,其降脂、抗炎、改善颅内动脉血流动力学作用更加明显。

Objective：To analyze influence of probucol combined atorvastatin on hemodynamics and blood lipids in patients with large artery cerebral infarction（LACI）.Methods：A total of 92 LACI patients were randomly and equally divided into atorvastatin group and combined treatment group（received atorvastatin combined probucol）,both groups were treated for six months.Therapeutic effect etc indexes before and after treatment were compared between two groups.Results：Compared with atorvastatin group after six-month treatment,there were significant reductions in levels of TC [（4.57±0.82）mmol/L vs.（3.23±0.71）mmol/L],TG [（1.37±0.45）mmol/L vs.（1.02±0.34）mmol/L],LDL-C [（2.52±0.83）mmol/L vs.（1.50±0.54）mmol/L],oxidized low density lipoprotein[ox-LDL,（78.36±14.05）mg/L vs.（58.37±12.00）mg/L],left and right middle cerebral artery pulsatility index（PI）[left：（0.84±0.25）vs.（0.74±0.14）,right：（0.84±0.23）vs.（0.74±0.16）]and inflammatory factors,and significant rise in total effective rate（69.57% vs.89.13% P=0.020）,left and right middle cerebral systolic blood flow velocity（Vs）[left：（87.45±15.58）cm/s vs.（95.48±18.34）cm/s,right：（89.27±14.36）cm/s vs.（96.18±14.03）cm/s]and mean blood flow velocity（Vm）[left：（60.90±16.19）cm/s vs.（76.19±17.40）cm/s,right：（62.08±17.23）cm/s vs.（91.38±19.26）cm/s]in combined treatment group,P〈0.05 or0.01.There was no significant difference in drug adverse reactions incidence rate between two groups,P=1.000.Conclusion：Therapeutic effect of probucol combined atorvastatin is significantly better than that of pure atorvastatin on large artery cerebral infarction.It can more significantly improve blood lipids and intracranial artery hemodynamics with anti-inflammatory effects.