短期胰岛素强化联合α-硫辛酸治疗对2型糖尿病血清炎症因子及氧化应激水平的影响

Effect of short-term insulin intensification combined with α-lipoic acid on serum inflammatory factors and oxidative stress level in type 2 diabetes mellitus

目的探讨短期胰岛素强化联合α-硫辛酸治疗对2型糖尿病(T2DM)患者血清炎症因子及氧化应激水平的影响。方法将86例初诊T2DM患者随机分为观察组与对照组,各43例。观察组给予短期强化治疗联合α-硫辛酸治疗,对照组单纯给予短期胰岛素强化治疗。比较两组患者的临床疗效。结果治疗后,两组FPG、2 h PG及HbAlc水平均降低(P<0.05);但治疗后组间比较,差异无统计学意义(P>0.05)。治疗后,两组患者的HOMA-IS、HOMA-β、ISI、SOD水平及T-AOC均显著升高,HOMA-IR、hs-CRP、TNF-α、MDA水平均降低,且观察组均优于对照组(P<0.05)。两组患者的血糖达标率无统计学差异(P>0.05);观察组患者的血糖达标时间短于对照组,胰岛素用量少于对照组(P<0.05)。结论短期胰岛素强化联合α-硫辛酸治疗能够有效控制T2DM患者炎症反应并调节氧化应激状态,改善胰岛β细胞功能。

Objective To investigate the effect of short -term insulin intensification combined with α-lipoic acid onserum inflammatory factors and oxidative stress level in type 2 diabetes mellitus （T2DM）. Methods A total of 86 patientswho newly diagnosed as T2DM were randomly divided into observation group and control group, with 43 cases in eachgroup. The observation group was treated with short-term insulin intensification combined with α-lipoic acid, and thecontrol group was treated with short-term intensive insulin treatment alone. The clinical effects of the two groups werecompared. Results After treatment, the levels of FPG,2h PG and HbAlc decreased in both groups（P〈0.05）, but there wereno significant differences between the two groups （P〉0.05）. After treatment, the HOMA-IS, HOMA-β, ISI, levels of SODand T-AOC significantly increased in both groups, the HOMA-IR, the levels of hs-CRP, TNF-α and MDA decreased inboth groups, and those of the observation group were better than the control group （P〈0.05）. There was no significantdifference in compliance rate of blood glucose between the two groups （P〉0.05）. The compliance time of blood glucose inthe observation group was shorter than that of the control group, and the insulin dosage was less than that of the controlgroup（P〈0.05）. Conclusion Short-term insulin intensification combined with α-lipoic acid treatment in T2DM patients caneffectively control inflammatory response and regulate oxidative stress and improve islet β-cell function.