噻托溴铵不同给药方式对哮喘合并COPD患者的影响

Effect of different administration modes of tiotropium bromide on patients with asthma combined with COPD

目的探讨噻托溴铵不同给药方式对哮喘合并慢性阻塞性肺疾病(COPD)患者的影响。方法按照随机数字表法将120例哮喘合并COPD患者分为三组,各40例。A组早晚吸入2.5μg噻托溴铵,B组每晚吸入5.0μg噻托溴铵,C组早晚使用异丙托溴铵气雾剂。比较三组的治疗效果。结果 A组和B组的治疗总有效率、FEV_1AUC_((0～24 h))、FEV_(1(0～24 h))峰值和FEV_1谷值无显著差异(P>0.05),但均显著高于C组(P<0.05)。A组和B组的不良反应总发生率无显著差异(P>0.05),但均低于C组(P<0.05)。结论针对哮喘合并COPD应用早晚2次吸入2.5μg噻托溴铵和每晚吸入5.0μg噻托溴铵两种给药方式均可明显提高治疗效果,改善临床症状,减少不良反应,因此临床可根据实际情况进行选择。

Objective To explore the effect of different administration modes of tiotropium bromide on patients withasthma combined with chronic obstruction pulmonary disease （COPD）. Methods A total of 120 patients with asthmacombined with COPD were divided into 3 groups by random number table method, with 40 cases in each group. Patients inthe group A inhaled 2.5 μg of tiotropium bromide in the morning and evening, patients in the group B inhaled 5.0 滋g oftiotropium bromide only in the evening, patients in the groupC were given ipratropium bromide aerosol in the morning andevening. The treatment effects of the three groups were compared. Results There were no significant differences in totaleffective rate of treatment, FEV1AUC（0-24 h）, FEV1（0-24 h） peak value and FEV1 valley value between the group A and groupB（P〉0.05）, but those were significantly higher than the groupC （P〈0.05）. There was no significant difference in the totalincidence of adverse reactions between the group A and group B（P〉0.05）, but those were lower than the group C（P〈0.05）.Conclusion Inhalation of 2.5 μg tiotropium bromide twice daily and 5.0 滋g tiotropium bromide per night for patients withasthma combined with COPD can significantly improve the treatment effect and clinical symptoms, reduce adversereactions. So it can be selected according to the actual situation in ilinic.