盐酸氨溴索雾化吸入联合静脉注射治疗新生儿肺炎的临床疗效

Clinical effect of aerosol inhalation combined with intravenous injection of ambroxol hydrochloride for neonatal pneumonia

目的观察盐酸氨溴索雾化吸入联合静脉注射治疗新生儿肺炎的临床效果。方法选取2016年9月至2017年9月我院新生儿科收治的76例新生儿肺炎患儿,将患儿随机分为对照组和研究组,每组38例。对照组患儿给予静脉注射盐酸氨溴索治疗,研究组患儿给予盐酸氨溴索雾化吸入联合静脉注射治疗,比较两组患儿的临床治疗总有效率、住院时间、血气分析恢复正常时间、肺部啰音消失时间、呼吸频率恢复正常时间、不良反应发生情况及血炎性因了水平。结果研究组治疗总有效率高于对照组(P<0.05)。研究组血气分析恢复正常时间、呼吸频率恢复正常时间、肺部啰音消失时间和住院时间明显短于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。研究组患儿血清炎性因子IL-6水平明显低于对照组(P<0.05)。结论盐酸氨溴索雾化吸入联合静脉注射治疗新生儿肺炎的效果显著,不仅能够改善患儿的临床症状,还可缩短治疗时间,具有良好的临床推广价值。

Objective To observe the clinical effect of aerosol inhalation combined with intravenous injection ofambroxol hydrochloride for neonatal pneumonia. Methods A total of 76 children with neonatal pneumonia from September2016 to September 2017 in neonatology department of our hospital were randomly divided into control group and studygroup, with 38 cases in each group. The control group was treated with intravenous injection of ambroxol hydrochloride,and the study group was given aerosol inhalation combined with intravenous injection of ambroxol hydrochloride. The totalclinical efficacy, the hospital stay, the blood gas analysis returned to normal time, the pulmonary rales disappearance time,the respiratory rate returned to normal time, the incidences of adverse events and the levels of serum inflammatory factorswere compared between the two groups. Results The total effective rate of treatment in the study group was higher than thatof the control group （P〈0.05）. The blood gas analysis returned to normal time, the respiratory rate returned to normal time,the pulmonary rales disappearance time, the hospital stay of the study group were significantly shorter than those of thecontrol group （P〈0.05）. There was no significant difference in the total incidence of adverse reations between the twogroups（P〉0.05）. The levels of serum inflammatory factors IL-6 in the study group were significantly lower than those in thecontrol group （P〈0.05）. Conclusion Ambroxol hydrochloride aerosol inhalation combined with intravenous injection hasobvious effects in the treatment of neonatal pneumonia, which not only can improve the clinical symptoms of children, butalso shorten the treatment time, and has good clinical promotion value.